TY - JOUR
T1 - Cancer progression
T2 - a single cell perspective
AU - Ermini, L.
AU - Taurone, S.
AU - Greco, A.
AU - Artico, M.
N1 - Funding
This study was supported by the following funding agencies and foundations: Finanziamento di Ateneo Università “Sapienza” 2019 No. RM11916B23EF2223
PY - 2023/6/1
Y1 - 2023/6/1
N2 - Tumor tissues are constituted by a dynamic diversity of malignant and non-malignant cells, which shape a puzzling biological ecosystem affecting cancer biology and response to treatments. Over the course of the tumoral disease, cancer cells acquire genotypic and phenotypic changes, allowing them to improve cellular fitness and overcome environmental and treatment constraints. This progression is depicted by an evolutionary process in which single cells expand as a result of an interaction between single-cell changes and the local microenvironment. Recent technological developments have made it possible to depict the development of cancer at the single-cell level, offering a novel method for understanding the biology of this complex disease. Here, we review those complex interactions from the perspective of single cells and introduce the concept of omics for single-cell studies. This review emphasizes the evolutionary dynamics that control cancer progression and the capacity of single cells to escape the local environment and colonize distant sites. We are assisting a rapid progression of studies carried out at the single-cell level, and we survey relevant single-cell technologies looking at multi-omics studies. These forefront approaches will address the combined contribution of both genetic and non-genetic factors to cancer progression and will pave the path for precision medicine in cancer.
AB - Tumor tissues are constituted by a dynamic diversity of malignant and non-malignant cells, which shape a puzzling biological ecosystem affecting cancer biology and response to treatments. Over the course of the tumoral disease, cancer cells acquire genotypic and phenotypic changes, allowing them to improve cellular fitness and overcome environmental and treatment constraints. This progression is depicted by an evolutionary process in which single cells expand as a result of an interaction between single-cell changes and the local microenvironment. Recent technological developments have made it possible to depict the development of cancer at the single-cell level, offering a novel method for understanding the biology of this complex disease. Here, we review those complex interactions from the perspective of single cells and introduce the concept of omics for single-cell studies. This review emphasizes the evolutionary dynamics that control cancer progression and the capacity of single cells to escape the local environment and colonize distant sites. We are assisting a rapid progression of studies carried out at the single-cell level, and we survey relevant single-cell technologies looking at multi-omics studies. These forefront approaches will address the combined contribution of both genetic and non-genetic factors to cancer progression and will pave the path for precision medicine in cancer.
KW - Humans
KW - Ecosystem
KW - Neoplasms/genetics
KW - Tumor Microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85163974158&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/37401310
U2 - 10.26355/eurrev_202306_32812
DO - 10.26355/eurrev_202306_32812
M3 - Article
C2 - 37401310
SN - 1128-3602
VL - 27
SP - 5721
EP - 5747
JO - European Review for Medical and Pharmacological Sciences
JF - European Review for Medical and Pharmacological Sciences
IS - 12
ER -