Bridging the gap with multispecific immune cell engagers in cancer and infectious diseases

Camille Rolin*, Jacques Zimmer, Carole Seguin-Devaux

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


By binding to multiple antigens simultaneously, multispecific antibodies are expected to substantially improve both the activity and long-term efficacy of antibody-based immunotherapy. Immune cell engagers, a subclass of antibody-based constructs, consist of engineered structures designed to bridge immune effector cells to their target, thereby redirecting the immune response toward the tumor cells or infected cells. The increasing number of recent clinical trials evaluating immune cell engagers reflects the important role of these molecules in new therapeutic approaches for cancer and infections. In this review, we discuss how different immune cell types (T and natural killer lymphocytes, as well as myeloid cells) can be bound by immune cell engagers in immunotherapy for cancer and infectious diseases. Furthermore, we explore the preclinical and clinical advancements of these constructs, and we discuss the challenges in translating the current knowledge from cancer to the virology field. Finally, we speculate on the promising future directions that immune cell engagers may take in cancer treatment and antiviral therapy.

Original languageEnglish
Pages (from-to)643-661
Number of pages19
JournalCellular and Molecular Immunology
Issue number7
Early online date24 May 2024
Publication statusPublished - Jul 2024


  • Cancer
  • Immune cell engagers
  • Immunotherapy
  • Multispecific antibodies
  • Virus


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