Bone remodeling and hydroxyapatite resorption in coated primary hip prostheses

Alphons J. Tonino, Bart C.H. Van Der Wal, Ide C. Heyligers, Bernd Grimm

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Abstract

Hydroxyapatite coatings for THA promote bone ongrowth, but bone and coating are exposed to stress shielding-driven osteoclastic resorption. We asked: (1) if the resorption of hydroxyapatite coating and bone ongrowth correlated with demographics; (2) if the resorption related to the stem level; and (3) what happens to the implant-bone interface when all hydroxyapatite coating is resorbed? We recovered 13 femoral components from cadaveric specimens 3.3 to 11.2 years after uneventful primary THA. Three cross sections (proximal, medial, distal) of the hydroxyapatite-coated proximal implant sleeve were analyzed by measuring the percentage of residual hydroxyapatite and bone ongrowth on the implant perimeter. Hydroxyapatite resorption was independent of patient age but increased with time in vivo and mostly was gone after 8 years. Bone ongrowth was independent of time in vivo but decreased with aging patients. Only in the most proximal section did less residual hydroxyapatite correlate with less bone ongrowth. Hydroxyapatite resorption, which was more proximal than distal, showed no adverse effects on the implant-bone interface.

Original languageEnglish
Pages (from-to)478-484
Number of pages7
JournalClinical Orthopaedics and Related Research
Volume467
Issue number2
DOIs
Publication statusPublished - Feb 2009
Externally publishedYes

Fingerprint

Dive into the research topics of 'Bone remodeling and hydroxyapatite resorption in coated primary hip prostheses'. Together they form a unique fingerprint.

Cite this