Blood Pressure Drop Prediction by using HRV Measurements in Orthostatic Hypotension

Giovanna Sannino*, Paolo Melillo, Saverio Stranges, Giuseppe De Pietro, Leandro Pecchia

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)


Orthostatic Hypotension is defined as a reduction of systolic and diastolic blood pressure within 3 minutes of standing, and may cause dizziness and loss of balance. Orthostatic Hypotension has been considered an important risk factor for falls since 1960. This paper presents a model to predict the systolic blood pressure drop due to orthostatic hypotension, relying on heart rate variability measurements extracted from 5 minute ECGs recorded before standing. This model was developed and validated with the leave-one-out cross-validation technique involving 10 healthy subjects, and finally tested with an additional 5 healthy subjects, whose data were not used during the training and cross-validation process. The results show that the model predicts correctly the systolic blood pressure drop in 80 % of all experiments, with an error rate below the measurement error of a sphygmomanometer digital device.

Original languageEnglish
Article number143
JournalJournal of Medical Systems
Issue number11
Publication statusPublished - 13 Nov 2015


  • Drop blood pressure prediction
  • Falls in later life
  • Heart rate variability
  • Orthostatic hypotension


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