TY - JOUR
T1 - Blood-based biomarker in Parkinson’s disease
T2 - potential for future applications in clinical research and practice
AU - Tönges, Lars
AU - Buhmann, Carsten
AU - Klebe, Stephan
AU - Klucken, Jochen
AU - Kwon, Eun Hae
AU - Müller, Thomas
AU - Pedrosa, David J.
AU - Schröter, Nils
AU - Riederer, Peter
AU - Lingor, Paul
N1 - Funding: Open Access funding enabled and organized by Projekt DEAL.Publisher Copyright:
© 2022, The Author(s).
PY - 2022/9
Y1 - 2022/9
N2 - The clinical presentation of Parkinson’s disease (PD) is both complex and heterogeneous, and its precise classification often requires an intensive work-up. The differential diagnosis, assessment of disease progression, evaluation of therapeutic responses, or identification of PD subtypes frequently remains uncertain from a clinical point of view. Various tissue- and fluid-based biomarkers are currently being investigated to improve the description of PD. From a clinician's perspective, signatures from blood that are relatively easy to obtain would have great potential for use in clinical practice if they fulfill the necessary requirements as PD biomarker. In this review article, we summarize the knowledge on blood-based PD biomarkers and present both a researcher’s and a clinician’s perspective on recent developments and potential future applications.
AB - The clinical presentation of Parkinson’s disease (PD) is both complex and heterogeneous, and its precise classification often requires an intensive work-up. The differential diagnosis, assessment of disease progression, evaluation of therapeutic responses, or identification of PD subtypes frequently remains uncertain from a clinical point of view. Various tissue- and fluid-based biomarkers are currently being investigated to improve the description of PD. From a clinician's perspective, signatures from blood that are relatively easy to obtain would have great potential for use in clinical practice if they fulfill the necessary requirements as PD biomarker. In this review article, we summarize the knowledge on blood-based PD biomarkers and present both a researcher’s and a clinician’s perspective on recent developments and potential future applications.
KW - Alpha-synuclein
KW - Biomarker
KW - Parkinsonian syndromes
KW - Parkinson’s disease
UR - http://www.scopus.com/inward/record.url?scp=85128172982&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/35428925
U2 - 10.1007/s00702-022-02498-1
DO - 10.1007/s00702-022-02498-1
M3 - Review article
C2 - 35428925
AN - SCOPUS:85128172982
SN - 0300-9564
VL - 129
SP - 1201
EP - 1217
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
IS - 9
ER -