Biotin interference can cause false-negative specific IgE results in patients with anaphylaxis

Nils Scheib, Daniel Bauersachs, Dimitrii Pogorelov, Charlotte Mara Heinrich, Feng Q Hefeng, Carsten Bindslev-Jensen, Chrysanthi Skevaki, Markus Ollert*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Clinical Implications
High-dose supplemental biotin can ablate allergen-specific IgE detection in sera from patients with a history of allergy or anaphylaxis on the one-step IMMULITE-2000 autoanalyzer.
Thus, clinicians relying on this immunoassay should inquire about biotin intake with patients during the visit.
Original languageEnglish
Pages (from-to)2459-2462.e2
JournalJournal of Allergy and Clinical Immunology: In Practice
Volume10
Issue number9
Early online date30 May 2022
DOIs
Publication statusPublished - Sep 2022

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