TY - JOUR
T1 - Biotin interference can cause false-negative specific IgE results in patients with anaphylaxis
AU - Scheib, Nils
AU - Bauersachs, Daniel
AU - Pogorelov, Dimitrii
AU - Heinrich, Charlotte Mara
AU - Hefeng, Feng Q
AU - Bindslev-Jensen, Carsten
AU - Skevaki, Chrysanthi
AU - Ollert, Markus
N1 - Funding Information:
This work was partially supported by the Luxembourg National Research Fund (Fonds National de la Recherche/FNR) through the FNR-PRIDE program (PRIDE/11012546/NEXTIMMUNE) and the Ministry of Higher Education and Research of Luxembourg through Luxembourg Institute of Health (LIH) intramural funding. C. Skevaki is supported by the Universities Giessen and Marburg Lung Center, the German Center for Lung Research, University Hospital Giessen and Marburg research funding according to Article 2, Section 3 cooperation agreement, and Deutsche Forschungsgemeinschaft–funded SFB 1021 (C04), KFO 309 (P10), and SK 317/1-1 (Project 428518790) as well as by the Foundation for Pathobiochemistry and Molecular Diagnostics. Conflicts of interest: M. Ollert has been a consultant for HYCOR Biomedical, Siemens Healthineers, and Hitachi Chemical Diagnostics; and a speaker for Thermo Fisher Scientific, Siemens Healthineers, HYCOR Biomedical, and Allergy Therapeutics. C. Skevaki is a consultant and receives research funding from HYCOR Biomedical, Bencard Allergie, and Thermo Fisher Scientific; and receives research funding from Mead Johnson Nutrition. The rest of the authors declare that they have no relevant conflicts of interest.
Funding Information:
Conflicts of interest: M. Ollert has been a consultant for HYCOR Biomedical, Siemens Healthineers, and Hitachi Chemical Diagnostics; and a speaker for Thermo Fisher Scientific, Siemens Healthineers, HYCOR Biomedical, and Allergy Therapeutics. C. Skevaki is a consultant and receives research funding from HYCOR Biomedical, Bencard Allergie, and Thermo Fisher Scientific; and receives research funding from Mead Johnson Nutrition. The rest of the authors declare that they have no relevant conflicts of interest.
Funding Information:
This work was partially supported by the Luxembourg National Research Fund (Fonds National de la Recherche/FNR) through the FNR-PRIDE program (PRIDE/11012546/NEXTIMMUNE) and the Ministry of Higher Education and Research of Luxembourg through Luxembourg Institute of Health (LIH) intramural funding. C. Skevaki is supported by the Universities Giessen and Marburg Lung Center , the German Center for Lung Research , University Hospital Giessen and Marburg research funding according to Article 2, Section 3 cooperation agreement, and Deutsche Forschungsgemeinschaft–funded SFB 1021 (C04), KFO 309 (P10), and SK 317/1-1 (Project 428518790) as well as by the Foundation for Pathobiochemistry and Molecular Diagnostics.
PY - 2022/9
Y1 - 2022/9
N2 - Clinical ImplicationsHigh-dose supplemental biotin can ablate allergen-specific IgE detection in sera from patients with a history of allergy or anaphylaxis on the one-step IMMULITE-2000 autoanalyzer.Thus, clinicians relying on this immunoassay should inquire about biotin intake with patients during the visit.
AB - Clinical ImplicationsHigh-dose supplemental biotin can ablate allergen-specific IgE detection in sera from patients with a history of allergy or anaphylaxis on the one-step IMMULITE-2000 autoanalyzer.Thus, clinicians relying on this immunoassay should inquire about biotin intake with patients during the visit.
UR - http://www.scopus.com/inward/record.url?scp=85132693423&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/35654368
U2 - 10.1016/j.jaip.2022.05.021
DO - 10.1016/j.jaip.2022.05.021
M3 - Article
C2 - 35654368
VL - 10
SP - 2459-2462.e2
JO - Journal of Allergy and Clinical Immunology: In Practice
JF - Journal of Allergy and Clinical Immunology: In Practice
SN - 2213-2198
IS - 9
ER -