Biospecimen Qualification in a Clinical Biobank of Urological Diseases

Olga Kofanova, Sangita Paul, Achilleas Pexaras, Camille Bellora, Ala Petersons, Margaux Schmitt, Mohamad Baker Berjaoui, Yazan Qaoud, Miran Kenk, Heidi Wagner, Neil Fleshner, Fay Betsou

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Development of novel biomarkers for diagnosis of disease and assessment of treatment efficacy utilizes a wide range of biospecimens for discovery research. The fitness of biospecimens for the purpose of biomarker development depends on the clinical characteristics of the donor and on a number of critical and potentially uncontrolled pre-analytical variables. Pre-analytical factors influence the reliability of the biomarkers to be analyzed and can seriously impact analytic outcomes. Sample quality stratification assays and tools can be utilized by biorepositories to minimize bias resulting from samples’ inconsistent quality. In this study, we evaluated the quality of biobanked specimens by comparing analytical outcomes at 1, 5, and 10 years after collection. Our results demonstrate that currently available assays and tools can be used by biobank laboratories to support objective biospecimen qualification. We have established a workflow to monitor the quality of different types of biospecimens and, in this study, present the results of a qualification exercise applied to fluid samples and their derivatives in the context of urological diseases.

Original languageEnglish
JournalBiopreservation and Biobanking
Early online date25 Oct 2023
DOIs
Publication statusE-pub ahead of print - 25 Oct 2023

Keywords

  • biospecimen
  • pre-analytical factors
  • qualification
  • sample quality stratification

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