Biologie des radiations: avancées majeures et perspectives pour la radiothérapie

Translated title of the contribution: Radiation biology: Major advances and perspectives for radiotherapy.

A. Joubert, G. Vogin, C. Devic, A. Granzotto, M. Viau, M. Maalouf, C. Thomas, C. Colin, N. Foray*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

19 Citations (Scopus)


At the beginning of the 21st century, radiation biology is at a major turning point in its history. It must meet the expectations of the radiation oncologists, radiologists and the general public, but its purpose remains the same: to understand the molecular, cellular and tissue levels of lethal and carcinogenic effects of ionizing radiation in order to better protect healthy tissues and to develop treatments more effective against tumours. Four major aspects of radiobiology that marked this decade will be discussed: technological developments, the importance of signalling and repair of radiation-induced deoxyribonucleic acid (DNA) damage, the impact of individual factor in the response to radiation and the contribution of radiobiology to better choose innovative therapies such as protontherapy or stereotactic body radiation therapy (SBRT). A translational radiobiology should emerge with the help of radiotherapists and radiation physicists and by facilitating access to the new radio and/or chemotherapy modalities.

Translated title of the contributionRadiation biology: Major advances and perspectives for radiotherapy.
Original languageFrench
Pages (from-to)348-354
Number of pages7
JournalCancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
Issue number5
Publication statusPublished - Aug 2011
Externally publishedYes


  • Cancer proneness
  • DNA repair
  • Radiobiology
  • Radiosensitivity


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