Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinases

Ramesh Ekambaram; Erki Enkvist; Ganesh Babu Manoharan; Mihkel Ugandi; Marje Kasari; Kaido Viht; Stefan Knapp; Olaf Georg Issinger; Asko Uri

doi:10.1039/c3cc49198f

Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinases

Ramesh Ekambaram, Erki Enkvist, Ganesh Babu Manoharan, Mihkel Ugandi, Marje Kasari, Kaido Viht, Stefan Knapp, Olaf Georg Issinger, Asko Uri^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

25 Citations (Scopus)

Abstract

Benzoselenadiazole-containing inhibitors of protein kinases were constructed and their capability to emit phosphorescence in the kinase-bound state was established. Labelling of the inhibitors with a red fluorescent dye led to sensitive responsive photoluminescent probes for protein kinase CK2 that emitted red light with a long (microsecond-scale) decay time upon excitation of the probes with a pulse of near-UV light.

Original language	English
Pages (from-to)	4096-4098
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	31
DOIs	https://doi.org/10.1039/c3cc49198f
Publication status	Published - 20 Mar 2014
Externally published	Yes

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abstract = "Benzoselenadiazole-containing inhibitors of protein kinases were constructed and their capability to emit phosphorescence in the kinase-bound state was established. Labelling of the inhibitors with a red fluorescent dye led to sensitive responsive photoluminescent probes for protein kinase CK2 that emitted red light with a long (microsecond-scale) decay time upon excitation of the probes with a pulse of near-UV light.",

author = "Ramesh Ekambaram and Erki Enkvist and Manoharan, \{Ganesh Babu\} and Mihkel Ugandi and Marje Kasari and Kaido Viht and Stefan Knapp and Issinger, \{Olaf Georg\} and Asko Uri",

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AU - Ekambaram, Ramesh

AU - Enkvist, Erki

AU - Manoharan, Ganesh Babu

AU - Ugandi, Mihkel

AU - Kasari, Marje

AU - Viht, Kaido

AU - Knapp, Stefan

AU - Issinger, Olaf Georg

AU - Uri, Asko

PY - 2014/3/20

Y1 - 2014/3/20

N2 - Benzoselenadiazole-containing inhibitors of protein kinases were constructed and their capability to emit phosphorescence in the kinase-bound state was established. Labelling of the inhibitors with a red fluorescent dye led to sensitive responsive photoluminescent probes for protein kinase CK2 that emitted red light with a long (microsecond-scale) decay time upon excitation of the probes with a pulse of near-UV light.

AB - Benzoselenadiazole-containing inhibitors of protein kinases were constructed and their capability to emit phosphorescence in the kinase-bound state was established. Labelling of the inhibitors with a red fluorescent dye led to sensitive responsive photoluminescent probes for protein kinase CK2 that emitted red light with a long (microsecond-scale) decay time upon excitation of the probes with a pulse of near-UV light.

UR - https://www.scopus.com/pages/publications/84897869865

U2 - 10.1039/c3cc49198f

DO - 10.1039/c3cc49198f

M3 - Article

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AN - SCOPUS:84897869865

SN - 1359-7345

VL - 50

SP - 4096

EP - 4098

JO - Chemical Communications

JF - Chemical Communications

IS - 31

ER -

Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinases

Abstract

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