Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinases

Ramesh Ekambaram, Erki Enkvist, Ganesh Babu Manoharan, Mihkel Ugandi, Marje Kasari, Kaido Viht, Stefan Knapp, Olaf Georg Issinger, Asko Uri*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Abstract

Benzoselenadiazole-containing inhibitors of protein kinases were constructed and their capability to emit phosphorescence in the kinase-bound state was established. Labelling of the inhibitors with a red fluorescent dye led to sensitive responsive photoluminescent probes for protein kinase CK2 that emitted red light with a long (microsecond-scale) decay time upon excitation of the probes with a pulse of near-UV light.

Original languageEnglish
Pages (from-to)4096-4098
Number of pages3
JournalChemical Communications
Volume50
Issue number31
DOIs
Publication statusPublished - 20 Mar 2014
Externally publishedYes

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