Beneficial effect of exercise on cognitive function during peripheral arterial disease: Potential involvement of myokines and microglial anti-inflammatory phenotype enhancement

Marina Leardini-Tristao, Anne Laure Charles, Anne Lejay, Mégane Pizzimenti, Alain Meyer, Vanessa Estato, Eduardo Tibiriçá, Emmanuel Andres, Bernard Geny*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)

Abstract

Peripheral arterial disease (PAD), leading to intermittent claudication, critical ischemia with rest pain, and/or tissue damage, is a public health issue associated with significant morbidity and mortality. Little is known about the link between PAD, cognitive function, and whether exercise might reduce cognitive dysfunction in PAD patients, as previously observed concerning both quality of life and prognosis. This review highlights the fact that patients suffering from PAD often demonstrate cognitive dysfunction characterized by reduced performance in nonverbal reasoning, reduced verbal fluency, and decreased information processing speed and a greater risk for progression toward dementia. Further, the data presented support that physical exercise, likely through myokine secretion and microglial anti-inflammatory phenotype enhancement, might participate in the cognition protection in common clinical settings.

Original languageEnglish
Article number653
JournalJournal of Clinical Medicine
Volume8
Issue number5
DOIs
Publication statusPublished - May 2019
Externally publishedYes

Keywords

  • Ankle-brachial index
  • BDNF
  • Brain
  • Cathepsin-B
  • Cognitive dysfunction
  • Exercise
  • Irisin
  • Microglia
  • Myokines
  • Peripheral arterial disease

Fingerprint

Dive into the research topics of 'Beneficial effect of exercise on cognitive function during peripheral arterial disease: Potential involvement of myokines and microglial anti-inflammatory phenotype enhancement'. Together they form a unique fingerprint.

Cite this