Being Efficient About Efficacy Estimation

Stephen Senn*

*Corresponding author for this work

    Research output: Contribution to journalArticleResearchpeer-review

    9 Citations (Scopus)


    I consider Bob O'Neill's important role in promoting regulatory science and, in particular, through the very influential series of lectures he gave in Basel more than 20 years ago, the effect on statistics in European regulation and ultimately on regulatory science in the United States. I provide a simple model of disappointment in drug development. I consider three approaches to improving efficiency in drug development and conclude that there are simple things we could be doing to reduce the cost with which information is obtained in drug development.

    Original languageEnglish
    Pages (from-to)204-210
    Number of pages7
    JournalStatistics in Biopharmaceutical Research
    Issue number3
    Publication statusPublished - Aug 2013


    • Analysis of covariance
    • Dichotomies
    • Flexible designs
    • Patient-by-treatment interaction
    • Pharmacogentics
    • Responder analysis


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