Being Efficient About Efficacy Estimation

Stephen Senn*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

I consider Bob O'Neill's important role in promoting regulatory science and, in particular, through the very influential series of lectures he gave in Basel more than 20 years ago, the effect on statistics in European regulation and ultimately on regulatory science in the United States. I provide a simple model of disappointment in drug development. I consider three approaches to improving efficiency in drug development and conclude that there are simple things we could be doing to reduce the cost with which information is obtained in drug development.

Original languageEnglish
Pages (from-to)204-210
Number of pages7
JournalStatistics in Biopharmaceutical Research
Volume5
Issue number3
DOIs
Publication statusPublished - Aug 2013

Keywords

  • Analysis of covariance
  • Dichotomies
  • Flexible designs
  • Patient-by-treatment interaction
  • Pharmacogentics
  • Responder analysis

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