Bacteria-derived nutrient recycling: How phagocytosed bacteria regulate macrophage metabolism

Andrea Riviello; Dirk Brenner

doi:10.1016/j.cmet.2025.03.018

Bacteria-derived nutrient recycling: How phagocytosed bacteria regulate macrophage metabolism

Andrea Riviello, Dirk Brenner^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate

Abstract

Macrophages are responsible for sensing, phagocytosing, and destroying bacteria, yet the metabolic fate of these internalized microbes remains largely unexplored. A recent study published by Lesbats et al. in Nature¹ uncovers how macrophages recycle some of the components from phagolysosomal degradation, using them as intermediates in various anabolic pathways and as fuel for oxidative phosphorylation.

Original language	English
Pages (from-to)	1046-1048
Number of pages	3
Journal	Cell Metabolism
Volume	37
Issue number	5
DOIs	https://doi.org/10.1016/j.cmet.2025.03.018
Publication status	Published - 6 May 2025

Keywords

Macrophages/metabolism
Phagocytosis
Bacteria/metabolism
Animals
Humans
Nutrients/metabolism
Phagosomes/metabolism

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10.1016/j.cmet.2025.03.018

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title = "Bacteria-derived nutrient recycling: How phagocytosed bacteria regulate macrophage metabolism",

abstract = "Macrophages are responsible for sensing, phagocytosing, and destroying bacteria, yet the metabolic fate of these internalized microbes remains largely unexplored. A recent study published by Lesbats et al. in Nature1 uncovers how macrophages recycle some of the components from phagolysosomal degradation, using them as intermediates in various anabolic pathways and as fuel for oxidative phosphorylation.",

keywords = "Macrophages/metabolism, Phagocytosis, Bacteria/metabolism, Animals, Humans, Nutrients/metabolism, Phagosomes/metabolism",

author = "Andrea Riviello and Dirk Brenner",

note = "Funding: The authors would like to thank the Luxembourg National Research Fund (FNR) for support (PRIDE21/167 49720). Publisher Copyright: {\textcopyright} 2025 Elsevier Inc.",

year = "2025",

month = may,

day = "6",

doi = "10.1016/j.cmet.2025.03.018",

language = "English",

volume = "37",

pages = "1046--1048",

journal = "Cell Metabolism",

issn = "1550-4131",

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number = "5",

}

TY - JOUR

T1 - Bacteria-derived nutrient recycling

T2 - How phagocytosed bacteria regulate macrophage metabolism

AU - Riviello, Andrea

AU - Brenner, Dirk

PY - 2025/5/6

Y1 - 2025/5/6

N2 - Macrophages are responsible for sensing, phagocytosing, and destroying bacteria, yet the metabolic fate of these internalized microbes remains largely unexplored. A recent study published by Lesbats et al. in Nature1 uncovers how macrophages recycle some of the components from phagolysosomal degradation, using them as intermediates in various anabolic pathways and as fuel for oxidative phosphorylation.

AB - Macrophages are responsible for sensing, phagocytosing, and destroying bacteria, yet the metabolic fate of these internalized microbes remains largely unexplored. A recent study published by Lesbats et al. in Nature1 uncovers how macrophages recycle some of the components from phagolysosomal degradation, using them as intermediates in various anabolic pathways and as fuel for oxidative phosphorylation.

KW - Macrophages/metabolism

KW - Phagocytosis

KW - Bacteria/metabolism

KW - Animals

KW - Humans

KW - Nutrients/metabolism

KW - Phagosomes/metabolism

UR - http://www.scopus.com/inward/record.url?scp=105003756467&partnerID=8YFLogxK

UR - https://pubmed.ncbi.nlm.nih.gov/40334642/

U2 - 10.1016/j.cmet.2025.03.018

DO - 10.1016/j.cmet.2025.03.018

M3 - Comment/debate

C2 - 40334642

AN - SCOPUS:105003756467

SN - 1550-4131

VL - 37

SP - 1046

EP - 1048

JO - Cell Metabolism

JF - Cell Metabolism

IS - 5

ER -

Bacteria-derived nutrient recycling: How phagocytosed bacteria regulate macrophage metabolism

Abstract

Keywords

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