TY - JOUR
T1 - Back to pupillometry
T2 - How cortical network state fluctuations tracked by pupil dynamics could explain neural signal variability in human cognitive neuroscience
AU - Schwalm, Miriam
AU - Jubal, Eduardo Rosales
N1 - Publisher Copyright:
© 2017 Schwalm and Rosales Jubal.
PY - 2017/11/1
Y1 - 2017/11/1
N2 - The mammalian thalamocortical system generates intrinsic activity reflecting different states of excitability, arising from changes in the membrane potentials of underlying neuronal networks. Fluctuations between these states occur spontaneously, regularly, and frequently throughout awake periods and influence stimulus encoding, information processing, and neuronal and behavioral responses. Changes of pupil size have recently been identified as a reliable marker of underlying neuronal membrane potential and thus can encode associated network state changes in rodent cortex. This suggests that pupillometry, a ubiquitous measure of pupil dilation in cognitive neuroscience, could be used as an index for network state fluctuations also for human brain signals. Considering this variable may explain task-independent variance in neuronal and behavioral signals that were previously disregarded as noise.
AB - The mammalian thalamocortical system generates intrinsic activity reflecting different states of excitability, arising from changes in the membrane potentials of underlying neuronal networks. Fluctuations between these states occur spontaneously, regularly, and frequently throughout awake periods and influence stimulus encoding, information processing, and neuronal and behavioral responses. Changes of pupil size have recently been identified as a reliable marker of underlying neuronal membrane potential and thus can encode associated network state changes in rodent cortex. This suggests that pupillometry, a ubiquitous measure of pupil dilation in cognitive neuroscience, could be used as an index for network state fluctuations also for human brain signals. Considering this variable may explain task-independent variance in neuronal and behavioral signals that were previously disregarded as noise.
KW - Network state changes
KW - Pupil diameter
KW - Pupillometry
UR - http://www.scopus.com/inward/record.url?scp=85039728802&partnerID=8YFLogxK
U2 - 10.1523/ENEURO.0293-16.2017
DO - 10.1523/ENEURO.0293-16.2017
M3 - Article
C2 - 29379876
AN - SCOPUS:85039728802
SN - 2373-2822
VL - 4
JO - eNeuro
JF - eNeuro
IS - 6
M1 - e0293-16.2017
ER -