B-Cell Metabolic Remodeling and Cancer

Davide G. Franchina, Melanie Grusdat, Dirk Brenner*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

48 Citations (Scopus)

Abstract

Cells of the immune system display varying metabolic profiles to fulfill their functions. B lymphocytes overcome fluctuating energy challenges as they transition from the resting state and recirculation to activation, rapid proliferation, and massive antibody production. Only through a controlled interplay between metabolism, extracellular stimuli, and intracellular signaling can successful humoral responses be mounted. Alterations to this balance can promote malignant transformation of B cells. The metabolic control of B-cell fate is only partially understood. Here, we provide a compelling overview of the current state of the art and describe the main metabolic features of B cells during normal development and oncogenesis, with emphasis on the major B-cell transcriptional and metabolic regulators, including myelocytomatosis virus oncogene cellular homolog (Myc) and hypoxia-inducible factor 1-α (HIF-1α).

Original languageEnglish
Pages (from-to)138-150
Number of pages13
JournalTrends in Cancer
Volume4
Issue number2
DOIs
Publication statusPublished - Feb 2018

Keywords

  • B cell
  • HIF-1α
  • Myc
  • immunometabolism
  • lymphoma

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