Asterolloside, a novel enolic saccharide from the sea star Asterias rollestoni Bell

Xian Wen Yang; Zi Miao; Xiao Ni Ma; Gai Yun Zhang; Andre Steinmetz; Bin Yang; Jun Feng Wang; Juan Liu; Yonghong Liu; Ning Wang

doi:10.1016/j.tetlet.2015.09.019

Asterolloside, a novel enolic saccharide from the sea star Asterias rollestoni Bell

Xian Wen Yang^*, Zi Miao, Xiao Ni Ma, Gai Yun Zhang, Andre Steinmetz, Bin Yang, Jun Feng Wang, Juan Liu, Yonghong Liu, Ning Wang

^*Corresponding author for this work

Department of Cancer Research

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

The first natural enolic glycoside, asterolloside (1), was isolated from the starfish Asterias rollestoni Bell together with two known tetrasaccharides. The structure of asterolloside was primarily elucidated by analysis of 1D and 2D NMR spectroscopic data. The absolute configuration was unambiguously determined by single-crystal Cu-Kα X-ray diffraction analysis. Asterolloside showed moderate α-glucosidase inhibitory activity with an inhibitory rate of 37.9% at a concentration of 0.12 mg/mL.

Original language	English
Pages (from-to)	6174-6176
Number of pages	3
Journal	Tetrahedron Letters
Volume	56
Issue number	45
DOIs	https://doi.org/10.1016/j.tetlet.2015.09.019
Publication status	Published - 4 Sept 2015

Keywords

Asterias rollestoni
Enolic saccharides
Starfish
α-Glucosidase

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10.1016/j.tetlet.2015.09.019

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title = "Asterolloside, a novel enolic saccharide from the sea star Asterias rollestoni Bell",

abstract = "The first natural enolic glycoside, asterolloside (1), was isolated from the starfish Asterias rollestoni Bell together with two known tetrasaccharides. The structure of asterolloside was primarily elucidated by analysis of 1D and 2D NMR spectroscopic data. The absolute configuration was unambiguously determined by single-crystal Cu-Kα X-ray diffraction analysis. Asterolloside showed moderate α-glucosidase inhibitory activity with an inhibitory rate of 37.9% at a concentration of 0.12 mg/mL.",

keywords = "Asterias rollestoni, Enolic saccharides, Starfish, α-Glucosidase",

author = "Yang, {Xian Wen} and Zi Miao and Ma, {Xiao Ni} and Zhang, {Gai Yun} and Andre Steinmetz and Bin Yang and Wang, {Jun Feng} and Juan Liu and Yonghong Liu and Ning Wang",

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T1 - Asterolloside, a novel enolic saccharide from the sea star Asterias rollestoni Bell

AU - Yang, Xian Wen

AU - Miao, Zi

AU - Ma, Xiao Ni

AU - Zhang, Gai Yun

AU - Steinmetz, Andre

AU - Yang, Bin

AU - Wang, Jun Feng

AU - Liu, Juan

AU - Liu, Yonghong

AU - Wang, Ning

PY - 2015/9/4

Y1 - 2015/9/4

N2 - The first natural enolic glycoside, asterolloside (1), was isolated from the starfish Asterias rollestoni Bell together with two known tetrasaccharides. The structure of asterolloside was primarily elucidated by analysis of 1D and 2D NMR spectroscopic data. The absolute configuration was unambiguously determined by single-crystal Cu-Kα X-ray diffraction analysis. Asterolloside showed moderate α-glucosidase inhibitory activity with an inhibitory rate of 37.9% at a concentration of 0.12 mg/mL.

AB - The first natural enolic glycoside, asterolloside (1), was isolated from the starfish Asterias rollestoni Bell together with two known tetrasaccharides. The structure of asterolloside was primarily elucidated by analysis of 1D and 2D NMR spectroscopic data. The absolute configuration was unambiguously determined by single-crystal Cu-Kα X-ray diffraction analysis. Asterolloside showed moderate α-glucosidase inhibitory activity with an inhibitory rate of 37.9% at a concentration of 0.12 mg/mL.

KW - Asterias rollestoni

KW - Enolic saccharides

KW - Starfish

KW - α-Glucosidase

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DO - 10.1016/j.tetlet.2015.09.019

M3 - Article

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SN - 0040-4039

VL - 56

SP - 6174

EP - 6176

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 45

ER -

Asterolloside, a novel enolic saccharide from the sea star Asterias rollestoni Bell

Abstract

Keywords

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