TY - JOUR
T1 - Associations between dietary patterns and longitudinal quality of life changes in colorectal cancer patients
T2 - The colocare study
AU - Gigic, Biljana
AU - Boeing, Heiner
AU - Toth, Reka
AU - Böhm, Jürgen
AU - Habermann, Nina
AU - Scherer, Dominique
AU - Schrotz-King, Petra
AU - Abbenhardt-Martin, Clare
AU - Skender, Stephanie
AU - Brenner, Hermann
AU - Chang-Claude, Jenny
AU - Hoffmeister, Michael
AU - Syrjala, Karen
AU - Jacobsen, Paul B.
AU - Schneider, Martin
AU - Ulrich, Alexis
AU - Ulrich, Cornelia M.
N1 - Funding Information:
Biljana Gigic was funded by the Matthias Lackas Foundation, the ERA-NET on Translational Cancer Research (TRANS-CAN) project 01KT1503, and the National Cancer Institute project R01CA189184. Dr. Cornelia M Ulrich and Dr. Ju€rgen Bohm were funded by the National Cancer Institute projects NIH R01 CA 189184 and NIH U01 CA 206110 and the Huntsman Cancer Foundation. Dr. Ulrich was further funded by NIH R01 CA207371. The Heidelberg ColoCare study was supported by the Matthias Lackas Foundation, the German Consortium of Translational Cancer Research (DKTK) and the Transcan-ERANET grant 01KT1503 (FOCUS consortium) and institutional funding from the German Cancer Research Center (DKFZ), Heidelberg, Germany to the Division of Preventive Oncology (Dr. Cornelia M. Ulrich, Dr. Hermann Brenner) at the National Center for Tumor Diseases (NCT), Heidelberg, Germany.
Funding Information:
Biljana Gigic was funded by the Matthias Lackas Foundation, the ERA-NET on Translational Cancer Research (TRANSCAN) project 01KT1503, and the National Cancer Institute project R01CA189184. Dr. Cornelia M Ulrich and Dr. J?rgen B?hm were funded by the National Cancer Institute projects NIH R01 CA 189184 and NIH U01 CA 206110 and the Huntsman Cancer Foundation. Dr. Ulrich was further funded by NIH R01 CA207371. The Heidelberg ColoCare study was supported by the Matthias Lackas Foundation, the German Consortium of Translational Cancer Research (DKTK) and the Transcan-ERANET grant 01KT1503 (FOCUS consortium) and institutional funding from the German Cancer Research Center (DKFZ), Heidelberg, Germany to the Division of Preventive Oncology (Dr. Cornelia M. Ulrich, Dr. Hermann Brenner) at the National Center for Tumor Diseases (NCT), Heidelberg, Germany.
Publisher Copyright:
© 2018 Taylor & Francis Group, LLC.
PY - 2018/12/13
Y1 - 2018/12/13
N2 - Quality of life (QoL) is an important clinical outcome in cancer patients. We investigated associations between dietary patterns and QoL changes in colorectal cancer (CRC) patients. The study included 192 CRC patients with available EORTC QLQ-C30 data before and 12 months post-surgery and food frequency questionnaire data at 12 months post-surgery. Principal component analysis was used to identify dietary patterns. Multivariate regression models assessed associations between dietary patterns and QoL changes over time. We identified four major dietary patterns: “Western” dietary pattern characterized by high consumption of potatoes, red and processed meat, poultry, and cakes, “fruit&vegetable” pattern: high intake of vegetables, fruits, vegetable oils, and soy products, “bread&butter” pattern: high intake of bread, butter and margarine, and “high-carb” pattern: high consumption of pasta, grains, nonalcoholic beverages, sauces and condiments. Patients following a “Western” diet had lower chances to improve in physical functioning (OR D 0.45 [0.21-0.99]), constipation (OR D 0.30 [0.13-0.72]) and diarrhea (OR: 0.44 [0.20-0.98]) over time. Patients following a “fruit&vegetable” diet showed improving diarrhea scores (OR: 2.52 [1.21-5.34]. A “Western” dietary pattern after surgery is inversely associated with QoL in CRC patients, whereas a diet rich in fruits and vegetables may be beneficial for patients’ QoL over time.
AB - Quality of life (QoL) is an important clinical outcome in cancer patients. We investigated associations between dietary patterns and QoL changes in colorectal cancer (CRC) patients. The study included 192 CRC patients with available EORTC QLQ-C30 data before and 12 months post-surgery and food frequency questionnaire data at 12 months post-surgery. Principal component analysis was used to identify dietary patterns. Multivariate regression models assessed associations between dietary patterns and QoL changes over time. We identified four major dietary patterns: “Western” dietary pattern characterized by high consumption of potatoes, red and processed meat, poultry, and cakes, “fruit&vegetable” pattern: high intake of vegetables, fruits, vegetable oils, and soy products, “bread&butter” pattern: high intake of bread, butter and margarine, and “high-carb” pattern: high consumption of pasta, grains, nonalcoholic beverages, sauces and condiments. Patients following a “Western” diet had lower chances to improve in physical functioning (OR D 0.45 [0.21-0.99]), constipation (OR D 0.30 [0.13-0.72]) and diarrhea (OR: 0.44 [0.20-0.98]) over time. Patients following a “fruit&vegetable” diet showed improving diarrhea scores (OR: 2.52 [1.21-5.34]. A “Western” dietary pattern after surgery is inversely associated with QoL in CRC patients, whereas a diet rich in fruits and vegetables may be beneficial for patients’ QoL over time.
UR - http://www.scopus.com/inward/record.url?scp=85038072655&partnerID=8YFLogxK
U2 - 10.1080/01635581.2018.1397707
DO - 10.1080/01635581.2018.1397707
M3 - Article
C2 - 29244538
AN - SCOPUS:85038072655
SN - 0163-5581
VL - 70
SP - 51
EP - 60
JO - Nutrition and Cancer
JF - Nutrition and Cancer
IS - 1
ER -