TY - JOUR
T1 - Association of hair polychlorinated biphenyls and multiclass pesticides with obesity, diabetes, hypertension and dyslipidemia in NESCAV study
AU - Peng, Feng Jiao
AU - Lin, Chia An
AU - Wada, Rin
AU - Bodinier, Barbara
AU - Iglesias-González, Alba
AU - Palazzi, Paul
AU - Streel, Sylvie
AU - Guillaume, Michèle
AU - Vuckovic, Dragana
AU - Chadeau-Hyam, Marc
AU - Appenzeller, Brice M.R.
AU - The NESCAV project group
N1 - Funding Information:
This work was supported by INTERREG IV A program “Greater Region” , 2007–2013.
Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2024/1/5
Y1 - 2024/1/5
N2 - Obesity, diabetes, hypertension and dyslipidemia are well-established risk factors for cardiovascular diseases (CVDs), and have been associated with exposure to persistent organic pollutants. However, studies have been lacking as regards effects of non-persistent pesticides on CVD risk factors. Here, we investigated whether background chronic exposure to polychlorinated biphenyls (PCBs) and multiclass pesticides were associated with the prevalence of these CVD risk factors in 502 Belgian and 487 Luxembourgish adults aged 18–69 years from the Nutrition, environment and cardiovascular health (NESCAV) study 2007–2013. We used hair analysis to evaluate the chronic internal exposure to three PCBs, seven organochlorine pesticides (OCs) and 18 non-persistent pesticides. We found positive associations of obesity with hexachlorobenzene (HCB), β-hexachlorocyclohexane (β-HCH) and chlorpyrifos, diabetes with pentachlorophenol (PCP), fipronil and fipronil sulfone, hypertension with PCB180 and chlorpyrifos, and dyslipidemia with diflufenican and oxadiazon, among others. However, we also found some inverse associations, such as obesity with PCP, diabetes with γ-HCH, hypertension with diflufenican, and dyslipidemia with chlorpyrifos. These results add to the existing evidence that OC exposure may contribute to the development of CVDs. Additionally, the present study revealed associations between CVD risk factors and chronic environmental exposure to currently used pesticides such as organophosphorus and pyrethroid pesticides.
AB - Obesity, diabetes, hypertension and dyslipidemia are well-established risk factors for cardiovascular diseases (CVDs), and have been associated with exposure to persistent organic pollutants. However, studies have been lacking as regards effects of non-persistent pesticides on CVD risk factors. Here, we investigated whether background chronic exposure to polychlorinated biphenyls (PCBs) and multiclass pesticides were associated with the prevalence of these CVD risk factors in 502 Belgian and 487 Luxembourgish adults aged 18–69 years from the Nutrition, environment and cardiovascular health (NESCAV) study 2007–2013. We used hair analysis to evaluate the chronic internal exposure to three PCBs, seven organochlorine pesticides (OCs) and 18 non-persistent pesticides. We found positive associations of obesity with hexachlorobenzene (HCB), β-hexachlorocyclohexane (β-HCH) and chlorpyrifos, diabetes with pentachlorophenol (PCP), fipronil and fipronil sulfone, hypertension with PCB180 and chlorpyrifos, and dyslipidemia with diflufenican and oxadiazon, among others. However, we also found some inverse associations, such as obesity with PCP, diabetes with γ-HCH, hypertension with diflufenican, and dyslipidemia with chlorpyrifos. These results add to the existing evidence that OC exposure may contribute to the development of CVDs. Additionally, the present study revealed associations between CVD risk factors and chronic environmental exposure to currently used pesticides such as organophosphorus and pyrethroid pesticides.
KW - Currently used pesticides
KW - CVD risk factors
KW - Hair analysis
KW - Persistent organic pollutants
KW - Pollutant mixture
UR - http://www.scopus.com/inward/record.url?scp=85173579947&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/37788552
U2 - 10.1016/j.jhazmat.2023.132637
DO - 10.1016/j.jhazmat.2023.132637
M3 - Article
C2 - 37788552
SN - 0304-3894
VL - 461
JO - Journal of Hazardous Materials
JF - Journal of Hazardous Materials
M1 - 132637
ER -