TY - JOUR
T1 - Association between stressful life events and cognitive disorders in central Africa
T2 - Results from the EPIDEMCA Program
AU - Pilleron, Sophie
AU - Guerchet, Maëlenn
AU - Ndamba-Bandzouzi, Bébène
AU - Mbelesso, Pascal
AU - Dartigues, Jean Francois
AU - Preux, Pierre Marie
AU - Clément, Jean Pierre
AU - Désormais, Iléana
AU - Lacroix, Philippe
AU - Aboyans, Victor
AU - Desport, Jean Claude
AU - Jésus, Pierre
AU - Tchalla, Achille E.
AU - Marin, Benoît
AU - Lambert, Jean Charles
AU - Preux., Pierre Marie
N1 - Publisher Copyright:
© 2015 S. Karger AG, Basel.
PY - 2015/4/24
Y1 - 2015/4/24
N2 - Background: Stressful life events (SLEs) are considered potential risk factors for cognitive disorders. Our objective was to investigate the association between SLEs and cognitive disorders among the elderly people in Central Africa. Method: A population-based study was conducted in the Central African Republic (CAR) and the Republic of Congo (ROC). Participants aged ≥65 were interviewed using the Community Screening Interview for Dementia. Those who performed poorly were clinically assessed by neurologists. DSM-IV and Petersen criteria were required for a diagnosis of dementia or mild cognitive impairment (MCI), respectively. SLEs were assessed through 18 questions about events that occurred during childhood, adulthood and late-life. Sociodemographic, vascular and psychological factors were also documented. Multivariate multinomial logistic regression models were used to estimate the associations. Results: MCI was positively associated with: the total number of SLEs (OR = 1.1, 95% CI: 1.0-1.2), the number of SLEs from the age of 65 (OR = 1.2, 95% CI: 1.0-1.3), the number of SLEs before the age of 16 among non-depressive participants (OR = 1.6, 95% CI: 1.2-2.2) and with a serious illness in a child experienced when the participant was aged 65 or more (OR = 2.8, 95% CI: 1.6-4.6). No association with dementia was observed. Conclusion: SLEs were positively associated with MCI but not dementia. More comprehensive studies are needed to further investigate this relationship.
AB - Background: Stressful life events (SLEs) are considered potential risk factors for cognitive disorders. Our objective was to investigate the association between SLEs and cognitive disorders among the elderly people in Central Africa. Method: A population-based study was conducted in the Central African Republic (CAR) and the Republic of Congo (ROC). Participants aged ≥65 were interviewed using the Community Screening Interview for Dementia. Those who performed poorly were clinically assessed by neurologists. DSM-IV and Petersen criteria were required for a diagnosis of dementia or mild cognitive impairment (MCI), respectively. SLEs were assessed through 18 questions about events that occurred during childhood, adulthood and late-life. Sociodemographic, vascular and psychological factors were also documented. Multivariate multinomial logistic regression models were used to estimate the associations. Results: MCI was positively associated with: the total number of SLEs (OR = 1.1, 95% CI: 1.0-1.2), the number of SLEs from the age of 65 (OR = 1.2, 95% CI: 1.0-1.3), the number of SLEs before the age of 16 among non-depressive participants (OR = 1.6, 95% CI: 1.2-2.2) and with a serious illness in a child experienced when the participant was aged 65 or more (OR = 2.8, 95% CI: 1.6-4.6). No association with dementia was observed. Conclusion: SLEs were positively associated with MCI but not dementia. More comprehensive studies are needed to further investigate this relationship.
KW - Central Africa
KW - Dementia
KW - Mild cognitive impairment
KW - Stressful life events
UR - http://www.scopus.com/inward/record.url?scp=84924672191&partnerID=8YFLogxK
U2 - 10.1159/000375462
DO - 10.1159/000375462
M3 - Article
C2 - 25765301
AN - SCOPUS:84924672191
SN - 0251-5350
VL - 44
SP - 99
EP - 107
JO - Neuroepidemiology
JF - Neuroepidemiology
IS - 2
ER -