Association between novelty-seeking and the dopamine D3 receptor gene in bipolar patients: A preliminary report

L. Staner*, C. Hilger, F. Hentges, J. Monreal, A. Hoffmann, M. Couturier, O. Le Bon, G. Stefos, D. Souery, J. Mendlewicz

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)

Abstract

Recent studies in healthy controls suggest an association between novelty-seeking (NS) and the dopamine D4 receptor (DRD4) gene. In this study, we further investigated the relationship between genes implicated in dopamine as well as serotonin neurotransmission and personality traits in bipolar (BP) disorder. Scores on the Tridimensional Personality Questionnaire were examined in 37 recovered Research Diagnostic Criteria-diagnosed BP patients genotyped for DRD3, DRD4, and serotonin 2A receptor (5HTR2a) polymorphisms. Carriers of DRD3 allele 1 showed significantly lower NS values compared to patients without this allele. Scores on NS and on harm-avoidance were not related to DRD4 or 5HTR2a polymorphisms. These preliminary results suggest a role for D3 receptor in NS expression in BP patients.

Original languageEnglish
Pages (from-to)192-194
Number of pages3
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume81
Issue number2
DOIs
Publication statusPublished - 28 Mar 1998

Keywords

  • Bipolar disorder
  • DRD3
  • DRD4
  • HTR2a
  • Novelty-seeking
  • TPQ

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