TY - JOUR
T1 - Association between Levels of Trimethylamine N-Oxide and Cancer
T2 - A Systematic Review and Meta-Analysis
AU - Khodabakhshi, Adeleh
AU - Monfared, Vahid
AU - Arabpour, Zahra
AU - Vahid, Farhad
AU - Hasani, Motahareh
N1 - Funding Information:
This paper was derived from the research project approvedand financed by Student Research Committee, Kerman University of Medical Sciences, under no 400000675.
Publisher Copyright:
© 2022 Taylor & Francis Group, LLC.
PY - 2023/1
Y1 - 2023/1
N2 - Cancer is the second leading cause of death in the world. Reports on the effect of Trimethylamine-N-oxide (TAMO), a small amine oxide generated by gut microbial metabolism of choline, betaine, and carnitine, on cancer are inconsistent. Therefore, this systematic review and meta-analysis summarize the effect of TAMO on cancer incidence. A systematic search was conducted in PubMed, Scopus, Web of Science, and Embase. Data were pooled using the random-effects method and were expressed as weighted mean difference (WMD) and 95% confidence intervals (CI). The pooled results of 16 studies, including 5930 participants, showed that the association between TMAO levels and cancer incidence is insignificant (Odds Ratio: 0.97, 95% CI: (0.64, 1.46), P-value = 0.871). Subgroup analysis showed that urinary TMAO levels were negatively associated with cancer incidence; in contrast, a direct and positive association was observed between serum TMAO levels and cancer incidence. However, “gender” and the “TMAO measuring method” were the potential sources of discrepancies. Meta-regression analysis did not reveal any significant association between duration of studies, age, female ratio, subjects-control, and subjects-case. The present study demonstrates that serum TAMO levels were insignificantly associated with cancer incidence.
AB - Cancer is the second leading cause of death in the world. Reports on the effect of Trimethylamine-N-oxide (TAMO), a small amine oxide generated by gut microbial metabolism of choline, betaine, and carnitine, on cancer are inconsistent. Therefore, this systematic review and meta-analysis summarize the effect of TAMO on cancer incidence. A systematic search was conducted in PubMed, Scopus, Web of Science, and Embase. Data were pooled using the random-effects method and were expressed as weighted mean difference (WMD) and 95% confidence intervals (CI). The pooled results of 16 studies, including 5930 participants, showed that the association between TMAO levels and cancer incidence is insignificant (Odds Ratio: 0.97, 95% CI: (0.64, 1.46), P-value = 0.871). Subgroup analysis showed that urinary TMAO levels were negatively associated with cancer incidence; in contrast, a direct and positive association was observed between serum TMAO levels and cancer incidence. However, “gender” and the “TMAO measuring method” were the potential sources of discrepancies. Meta-regression analysis did not reveal any significant association between duration of studies, age, female ratio, subjects-control, and subjects-case. The present study demonstrates that serum TAMO levels were insignificantly associated with cancer incidence.
UR - http://www.scopus.com/inward/record.url?scp=85139862252&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/36217110
U2 - 10.1080/01635581.2022.2129080
DO - 10.1080/01635581.2022.2129080
M3 - Review article
C2 - 36217110
SN - 0163-5581
VL - 75
SP - 402
EP - 414
JO - Nutrition and Cancer
JF - Nutrition and Cancer
IS - 2
ER -