TY - JOUR
T1 - Association between endometriosis and risk of type 2 diabetes
T2 - Results from the prospective E3N cohort
AU - Vaduva, Patricia
AU - Laouali, Nasser
AU - Fagherazzi, Guy
AU - Gelot, Amandine
AU - Bonnet, Fabrice
AU - Kvaskoff, Marina
N1 - Funding Information:
The E3N cohort from the French National Institute of Health and Medical Research (Inserm) was supported by the Mutuelle Générale de l'Education Nationale, the Gustave Roussy Institute, and the French League against Cancer (LNCC). E3N-E4N is also supported by the French National Research Agency (ANR) under the Investment for the future Program (PIA) (ANR-10-COHO-0006) and by the French Ministry of Higher Education, Research and Innovation (subsidy for public service charges #2102 918823). Nasser Laouali is supported by a research fellowship from the Fondation de France. This study is listed at clinicaltrials.gov as NCT03285230. Guy Fagherazzi is supported by the Luxembourg Institute of Health.
Funding Information:
The E3N cohort from the French National Institute of Health and Medical Research (Inserm) was supported by the Mutuelle Générale de l'Education Nationale , the Gustave Roussy Institute , and the French League against Cancer (LNCC). E3N-E4N is also supported by the French National Research Agency (ANR) under the Investment for the future Program (PIA) ( ANR-10-COHO-0006 ) and by the French Ministry of Higher Education, Research and Innovation (subsidy for public service charges # 2102 918823 ). Nasser Laouali is supported by a research fellowship from the Fondation de France. This study is listed at clinicaltrials.gov as NCT03285230 . Guy Fagherazzi is supported by the Luxembourg Institute of Health.
Publisher Copyright:
© 2023
PY - 2023/11
Y1 - 2023/11
N2 - Objective: Several studies suggest an association between endometriosis and the risk of cardio-metabolic diseases. This study aimed to prospectively evaluate the association between history of endometriosis and incident type 2 diabetes. Study design: E3N is a prospective cohort of 98,995 French women aged 40–65 years at inclusion. Multivariable Cox regression models were used to estimate hazard ratios and 95 % confidence intervals for the association between endometriosis and incident type 2 diabetes. We evaluated effect modification by age, body mass index, infertility treatment, adherence to the Mediterranean diet, and menopausal status. Results: Age at inclusion was 51 ± 6 years and there were 2672 incident cases of type 2 diabetes. A total of 4606 women reported surgically-confirmed endometriosis among 83,582 women with no history of diabetes at inclusion. Endometriosis was not associated with type 2 diabetes risk in a model adjusted for age, BMI, physical activity, smoking, education, age at menarche and oral contraceptive use (hazard ratio [HR] = 1.09; 95 % confidence interval [CI] = 0.92–1.29), neither after further adjustment for family history of diabetes, hypertension and menopausal status (HR = 0.97;95%CI = 0.80–1.16). The relationship did not differ by age at inclusion, BMI, infertility treatment, diet or menopausal status (p > 0.05). Conclusions: Surgically-confirmed endometriosis was not associated with the risk of type 2 diabetes in this large cohort, confirming that endometriosis is not a risk marker for type 2 diabetes.
AB - Objective: Several studies suggest an association between endometriosis and the risk of cardio-metabolic diseases. This study aimed to prospectively evaluate the association between history of endometriosis and incident type 2 diabetes. Study design: E3N is a prospective cohort of 98,995 French women aged 40–65 years at inclusion. Multivariable Cox regression models were used to estimate hazard ratios and 95 % confidence intervals for the association between endometriosis and incident type 2 diabetes. We evaluated effect modification by age, body mass index, infertility treatment, adherence to the Mediterranean diet, and menopausal status. Results: Age at inclusion was 51 ± 6 years and there were 2672 incident cases of type 2 diabetes. A total of 4606 women reported surgically-confirmed endometriosis among 83,582 women with no history of diabetes at inclusion. Endometriosis was not associated with type 2 diabetes risk in a model adjusted for age, BMI, physical activity, smoking, education, age at menarche and oral contraceptive use (hazard ratio [HR] = 1.09; 95 % confidence interval [CI] = 0.92–1.29), neither after further adjustment for family history of diabetes, hypertension and menopausal status (HR = 0.97;95%CI = 0.80–1.16). The relationship did not differ by age at inclusion, BMI, infertility treatment, diet or menopausal status (p > 0.05). Conclusions: Surgically-confirmed endometriosis was not associated with the risk of type 2 diabetes in this large cohort, confirming that endometriosis is not a risk marker for type 2 diabetes.
KW - Endometriosis
KW - Epidemiology
KW - Incidence
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85166629885&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/37531871
U2 - 10.1016/j.maturitas.2023.107805
DO - 10.1016/j.maturitas.2023.107805
M3 - Article
C2 - 37531871
SN - 0378-5122
VL - 177
JO - Maturitas
JF - Maturitas
M1 - 107805
ER -