@article{fbdd3997a42e4fe6a4ee37f97ec470a6,
title = "Association between dietary meat consumption and incident type 2 diabetes: The EPIC-InterAct study",
abstract = "Aims/hypothesis: A diet rich in meat has been reported to contribute to the risk of type 2 diabetes. The present study aims to investigate the association between meat consumption and incident type 2 diabetes in the EPIC-InterAct study, a large prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Methods: During 11.7 years of follow-up, 12,403 incident cases of type 2 diabetes were identified among 340,234 adults from eight European countries. A centre-stratified random subsample of 16,835 individuals was selected in order to perform a case-cohort design. Prentice-weighted Cox regression analyses were used to estimate HR and 95% CI for incident diabetes according to meat consumption. Results: Overall, multivariate analyses showed significant positive associations with incident type 2 diabetes for increasing consumption of total meat (50 g increments: HR 1.08; 95% CI 1.05, 1.12), red meat (HR 1.08; 95% CI 1.03, 1.13) and processed meat (HR 1.12; 95% CI 1.05, 1.19), and a borderline positive association with meat iron intake. Effect modifications by sex and class of BMI were observed. In men, the results of the overall analyses were confirmed. In women, the association with total and red meat persisted, although attenuated, while an association with poultry consumption also emerged (HR 1.20; 95% CI 1.07, 1.34). These associations were not evident among obese participants. Conclusions/interpretation: This prospective study confirms a positive association between high consumption of total and red meat and incident type 2 diabetes in a large cohort of European adults.",
keywords = "Case-cohort study, Diet, Meat, Type 2 diabetes",
author = "B. Bendinelli and D. Palli and G. Masala and Sharp, {S. J.} and Schulze, {M. B.} and M. Guevara and {van der A}, {D. L.} and F. Sera and P. Amiano and B. Balkau and A. Barricarte and H. Boeing and Crowe, {F. L.} and Dahm, {C. C.} and G. Dalmeijer and {de Lauzon-Guillain}, B. and R. Egeberg and G. Fagherazzi and Franks, {P. W.} and V. Krogh and Huerta, {J. M.} and P. Jakszyn and Khaw, {K. T.} and K. Li and A. Mattiello and Nilsson, {P. M.} and K. Overvad and F. Ricceri and L. Rodr{\'i}guez-Su{\'a}rez and O. Rolandsson and S{\'a}nchez, {M. J.} and N. Slimani and I. Sluijs and Spijkerman, {A. M.W.} and B. Teucher and A. Tjonneland and R. Tumino and {van den Berg}, {S. W.} and Forouhi, {N. G.} and C. Langenberg and Feskens, {E. J.M.} and E. Riboli and Wareham, {N. J.}",
note = "Funding Information: Funding The EPIC-InterAct study received funding from the European Union (Integrated Project LSHM-CT-2006-037197 in Framework Programme 6 of the European Community). In addition, InterAct investigators acknowledge funding from the following agencies: DP: Italian Association for Research on Cancer (AIRC) and PIO Programma Integrato Oncologia; DLvdA: Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands; FLC: Cancer Research UK; PWF: Swedish Research Council, Novo Nordisk, Swedish Diabetes Association, Swedish Heart–Lung Foundation; JMH: Health Research Fund of the Spanish Ministry of Health, Murcia Regional Government (no. 6236); KTK: Medical Research Council UK, Cancer Research UK; PMN: Swedish Research Council; KO: Danish Cancer Society; LR-S: Astu-rias Regional Government; OR: V{\"a}sterboten County Council; GD and IS: NL Agency grant IGE05012, incentive grant from the board of UMC Utrecht; AMWS: Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands; BT: German Cancer Aid; AT: Danish Cancer Society; RT: AIRE-ONLUS Ragusa, AVIS-Ragusa, Sicilian Regional Government; ER: Imperial College Biomedical Research Centre; PJ: Spanish Ministry of Health (ISCIII RETICC RD06/0020), Spanish Regional Governments of Andalusia, Asturias, Basque Country, Murcia (no. 6236) and Nav-arra, and the Catalan Institute of Oncology.",
year = "2013",
month = jan,
doi = "10.1007/s00125-012-2718-7",
language = "English",
volume = "56",
pages = "47--59",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer Verlag",
number = "1",
}