Assays for Qualification and Quality Stratification of Clinical Biospecimens Used in Research: A Technical Report from the ISBER Biospecimen Science Working Group

Fay Betsou; Alexandre Bulla; Sang Yun Cho; Judith Clements; Rodrigo Chuaqui; Domenico Coppola; Yvonne De Souza; Annemieke De Wilde; William Grizzle; Fiorella Guadagni; Elaine Gunter; Stacey Heil; Verity Hodgkinson; Joseph Kessler; Michael Kiehntopf; Hee Sung Kim; Iren Koppandi; Katheryn Shea; Rajeev Singh; Marc Sobel; Stella Somiari; Demetri Spyropoulos; Mars Stone; Gunnel Tybring; Klara Valyi-Nagy; Gert Van Den Eynden; Lalita Wadhwa

doi:10.1089/bio.2016.0018

Assays for Qualification and Quality Stratification of Clinical Biospecimens Used in Research: A Technical Report from the ISBER Biospecimen Science Working Group

Fay Betsou^*, Alexandre Bulla, Sang Yun Cho, Judith Clements, Rodrigo Chuaqui, Domenico Coppola, Yvonne De Souza, Annemieke De Wilde, William Grizzle, Fiorella Guadagni, Elaine Gunter, Stacey Heil, Verity Hodgkinson, Joseph Kessler, Michael Kiehntopf, Hee Sung Kim, Iren Koppandi, Katheryn Shea, Rajeev Singh, Marc SobelStella Somiari, Demetri Spyropoulos, Mars Stone, Gunnel Tybring, Klara Valyi-Nagy, Gert Van Den Eynden, Lalita Wadhwa

^*Corresponding author for this work

Biospecimen Research Group

Research output: Contribution to journal › Article › Research › peer-review

40 Citations (Scopus)

Abstract

This technical report presents quality control (QC) assays that can be performed in order to qualify clinical biospecimens that have been biobanked for use in research. Some QC assays are specific to a disease area. Some QC assays are specific to a particular downstream analytical platform. When such a qualification is not possible, QC assays are presented that can be performed to stratify clinical biospecimens according to their biomolecular quality.

Original language	English
Pages (from-to)	398-409
Number of pages	12
Journal	Biopreservation and Biobanking
Volume	14
Issue number	5
DOIs	https://doi.org/10.1089/bio.2016.0018
Publication status	Published - 1 Oct 2016

Keywords

biological fluid
biospecimen
cells
qualification
quality control
tissue

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10.1089/bio.2016.0018

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Betsou, F., Bulla, A., Cho, S. Y., Clements, J., Chuaqui, R., Coppola, D., De Souza, Y., De Wilde, A., Grizzle, W., Guadagni, F., Gunter, E., Heil, S., Hodgkinson, V., Kessler, J., Kiehntopf, M., Kim, H. S., Koppandi, I., Shea, K., Singh, R., ... Wadhwa, L. (2016). Assays for Qualification and Quality Stratification of Clinical Biospecimens Used in Research: A Technical Report from the ISBER Biospecimen Science Working Group. Biopreservation and Biobanking, 14(5), 398-409. https://doi.org/10.1089/bio.2016.0018

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title = "Assays for Qualification and Quality Stratification of Clinical Biospecimens Used in Research: A Technical Report from the ISBER Biospecimen Science Working Group",

abstract = "This technical report presents quality control (QC) assays that can be performed in order to qualify clinical biospecimens that have been biobanked for use in research. Some QC assays are specific to a disease area. Some QC assays are specific to a particular downstream analytical platform. When such a qualification is not possible, QC assays are presented that can be performed to stratify clinical biospecimens according to their biomolecular quality.",

keywords = "biological fluid, biospecimen, cells, qualification, quality control, tissue",

author = "Fay Betsou and Alexandre Bulla and Cho, {Sang Yun} and Judith Clements and Rodrigo Chuaqui and Domenico Coppola and {De Souza}, Yvonne and {De Wilde}, Annemieke and William Grizzle and Fiorella Guadagni and Elaine Gunter and Stacey Heil and Verity Hodgkinson and Joseph Kessler and Michael Kiehntopf and Kim, {Hee Sung} and Iren Koppandi and Katheryn Shea and Rajeev Singh and Marc Sobel and Stella Somiari and Demetri Spyropoulos and Mars Stone and Gunnel Tybring and Klara Valyi-Nagy and {Van Den Eynden}, Gert and Lalita Wadhwa",

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doi = "10.1089/bio.2016.0018",

language = "English",

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journal = "Biopreservation and Biobanking",

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Betsou, F, Bulla, A, Cho, SY, Clements, J, Chuaqui, R, Coppola, D, De Souza, Y, De Wilde, A, Grizzle, W, Guadagni, F, Gunter, E, Heil, S, Hodgkinson, V, Kessler, J, Kiehntopf, M, Kim, HS, Koppandi, I, Shea, K, Singh, R, Sobel, M, Somiari, S, Spyropoulos, D, Stone, M, Tybring, G, Valyi-Nagy, K, Van Den Eynden, G & Wadhwa, L 2016, 'Assays for Qualification and Quality Stratification of Clinical Biospecimens Used in Research: A Technical Report from the ISBER Biospecimen Science Working Group', Biopreservation and Biobanking, vol. 14, no. 5, pp. 398-409. https://doi.org/10.1089/bio.2016.0018

Assays for Qualification and Quality Stratification of Clinical Biospecimens Used in Research: A Technical Report from the ISBER Biospecimen Science Working Group. / Betsou, Fay; Bulla, Alexandre; Cho, Sang Yun et al.
In: Biopreservation and Biobanking, Vol. 14, No. 5, 01.10.2016, p. 398-409.

Research output: Contribution to journal › Article › Research › peer-review

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T2 - A Technical Report from the ISBER Biospecimen Science Working Group

AU - Betsou, Fay

AU - Bulla, Alexandre

AU - Cho, Sang Yun

AU - Clements, Judith

AU - Chuaqui, Rodrigo

AU - Coppola, Domenico

AU - De Souza, Yvonne

AU - De Wilde, Annemieke

AU - Grizzle, William

AU - Guadagni, Fiorella

AU - Gunter, Elaine

AU - Heil, Stacey

AU - Hodgkinson, Verity

AU - Kessler, Joseph

AU - Kiehntopf, Michael

AU - Kim, Hee Sung

AU - Koppandi, Iren

AU - Shea, Katheryn

AU - Singh, Rajeev

AU - Sobel, Marc

AU - Somiari, Stella

AU - Spyropoulos, Demetri

AU - Stone, Mars

AU - Tybring, Gunnel

AU - Valyi-Nagy, Klara

AU - Van Den Eynden, Gert

AU - Wadhwa, Lalita

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Y1 - 2016/10/1

N2 - This technical report presents quality control (QC) assays that can be performed in order to qualify clinical biospecimens that have been biobanked for use in research. Some QC assays are specific to a disease area. Some QC assays are specific to a particular downstream analytical platform. When such a qualification is not possible, QC assays are presented that can be performed to stratify clinical biospecimens according to their biomolecular quality.

AB - This technical report presents quality control (QC) assays that can be performed in order to qualify clinical biospecimens that have been biobanked for use in research. Some QC assays are specific to a disease area. Some QC assays are specific to a particular downstream analytical platform. When such a qualification is not possible, QC assays are presented that can be performed to stratify clinical biospecimens according to their biomolecular quality.

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KW - biospecimen

KW - cells

KW - qualification

KW - quality control

KW - tissue

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SN - 1947-5535

VL - 14

SP - 398

EP - 409

JO - Biopreservation and Biobanking

JF - Biopreservation and Biobanking

IS - 5

ER -

Assays for Qualification and Quality Stratification of Clinical Biospecimens Used in Research: A Technical Report from the ISBER Biospecimen Science Working Group

Abstract

Keywords

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