Asociacion entre leucemia linfatica cronica y anemia hemolitica autoinmune

Translated title of the contribution: Association between chronic lymphocytic leukemia and autoimmune hemolytic anemia

Jeremias Galletti*, Pablo Morande, Cristian Cañones, Mercedes Borge, Fernando Bezares, Romina Gamberale, Mirta Giordano

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review


The mechanisms underlying the frequent association between chronic lymphocytic leukemia (CLL) and autoimmune hemolytic anemia (AHA) remain ill-defined. In AHA autoantibodies are mostly directed to the erythrocyte proteins band 3 (B3), Rh complex or glycophorins. We explored the possibility that CLL cells could initiate the autoimmune response by presenting B3 to T cells in the context of appropriate costimulation. We first demonstrated that CLL cells are capable to bind and subsequently take up B3, but not other irrelevant proteins. The binding site for B3 in CLL cells is sensitive to protease and neuraminidase activity suggesting the involvement of a membrane glycoprotein. When CLL cells were used as antigen presenting cells for B3 we found that they were unable to induce T cell proliferation unless they were activated by CD40 engagement. Under these conditions, B3-pulsed CLL cells became capable of stimulating specific T cell responses in about 50% of the samples studied. Our results show that CLL cells can specifically bind and capture B3 and, after being activated, they can induce T cell proliferation. We propose that the leukemic clone could initiate the autoaggressive response to erythrocytes by acting as a population of B3-antigen presenting cells.

Translated title of the contributionAssociation between chronic lymphocytic leukemia and autoimmune hemolytic anemia
Original languageSpanish
Pages (from-to)51-54
Number of pages4
Issue numberSUPPL. 2
Publication statusPublished - 2007
Externally publishedYes


  • Autoimmune hemolytic anemia
  • Band 3
  • Chronic lymphocytic leukemia


Dive into the research topics of 'Association between chronic lymphocytic leukemia and autoimmune hemolytic anemia'. Together they form a unique fingerprint.

Cite this