Arterial stiffness and the reallocation of time between device-measured 24-hour movement behaviours: A compositional data analysis

the ORISCAV-LUX study group

Research output: Contribution to journalArticleResearchpeer-review


Background and aims: Arterial stiffness predicts cardiovascular morbidity and mortality. We aimed to quantify the differences in arterial stiffness associated with reallocating time between 24-h movement behaviours. Methods: This observational cross-sectional study included Luxembourg residents aged 25-79y who each provided ≥4 valid days of triaxial accelerometry (n = 1001). Covariable adjusted compositional isotemporal substitution models were used to examine if theoretical reallocations of time between device-measured sedentariness, the sleep period, light physical activity (PA), and moderate-to-vigorous PA (MVPA) were associated with the percentage difference in carotid-femoral pulse wave velocity (cfPWV). We further investigated if replacing sedentary time accumulated in prolonged (≥30 min) with non-prolonged (<30 min) bouts was associated with arterial stiffness. The results are presented as 30 min time exchanges (β (95% confidence interval)). Results: Beneficial associations with lower cfPWV were observed when reallocating time to MVPA from the sleep period (−1.38 (−2.63 to −0.12) %), sedentary time (−1.70 (−2.76 to −0.62) %), and light PA (−2.51 (−4.55 to −0.43) %), respectively. Larger associations in the opposite direction were observed when reallocating MVPA to the same behaviours (for example, replacing MVPA with sedentary time: 2.50 (0.85–4.18) %). Replacing prolonged with non-prolonged sedentary time was not associated with cfPWV (−0.27 (−0.86 to 0.32) %). In short sleepers, reallocating sedentary time to the sleep period was favourable (−1.96 (−3.74 to −0.15) %). Conclusions: Increasing or at least maintaining MVPA appears to be important for arterial health in adults. Extending sleep in habitually short sleepers, specifically by redistributing sedentary time, may also be important.

Original languageEnglish
Article number117185
Early online date5 Jul 2023
Publication statusPublished - Aug 2023


  • Inactivity
  • Physical activity
  • Precision medicine
  • Pulse wave velocity
  • Sleep
  • Vascular health


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