@article{defb13d926a3434f96e3e4b91422aee1,
title = "Aptamer Functionalization of Nanosystems for Glioblastoma Targeting through the Blood-Brain Barrier",
abstract = "Polymeric nanoparticles (PNPs) may efficiently deliver in vivo therapeutics to tumors when conjugated to specific targeting agents. Gint4.T aptamer specifically recognizes platelet-derived growth factor receptor β and can cross the blood-brain barrier (BBB). We synthesized Gint4.T-conjugated PNPs able of high uptake into U87MG glioblastoma (GBM) cells and with astonishing EC50 value (38 pM) when loaded with a PI3K-mTOR inhibitor. We also demonstrated in vivo BBB passage and tumor accumulation in a GBM orthotopic model.",
author = "Ilaria Monaco and Simona Camorani and David Colecchia and Erica Locatelli and Pierpaolo Calandro and Anais Oudin and Simone Niclou and Claudio Arra and Mario Chiariello and Laura Cerchia and \{Comes Franchini\}, Mauro",
note = "Funding Information: University of Bologna and Istituto Toscano Tumori are acknowledged for funding this project. The work was supported in part by IG AIRC (n. 18753 to L.C.). S.C. was supported by a Fondazione Umberto Veronesi Fellowship. Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",
year = "2017",
month = may,
day = "25",
doi = "10.1021/acs.jmedchem.7b00527",
language = "English",
volume = "60",
pages = "4510--4516",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "10",
}