TY - JOUR
T1 - Antigen 5 Allergens of Hymenoptera Venoms and Their Role in Diagnosis and Therapy of Venom Allergy
AU - Blank, Simon
AU - Bazon, Murilo Luiz
AU - Grosch, Johannes
AU - Schmidt-Weber, Carsten B.
AU - Brochetto-Braga, Márcia Regina
AU - Bilò, Maria Beatrice
AU - Jakob, Thilo
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Purpose of Review: Stings of Hymenoptera of the superfamily Vespoidea such as yellow jackets, paper wasps or stinging ants are common triggers for severe and even fatal allergic reactions. Antigen 5 allergens are potent allergens in the majority of these venoms with major importance for diagnosis and therapy. Reviewed here are the characteristics of antigen 5 allergens, their role in component-resolved diagnostics as well as current limitations of the available diagnostics for proper therapeutic decisions. Recent Findings: Antigens 5 are proteins of unknown function in Hymenoptera venoms with high allergenic potency. They represent key elements in component-resolved diagnosis to discriminate between honeybee and vespid venom allergy. However, due to their pronounced cross-reactivity, there are remaining diagnostic and therapeutic challenges that have to be addressed. Summary: Antigens 5 are highly relevant venom allergens of the Vespoidea superfamily. Although their use in component-resolved diagnosis facilitates dissection of cross-reactivity and primary allergy in double sensitization to honeybee and vespid venom, new diagnostic concepts are needed to discriminate between allergies to different vespid species.
AB - Purpose of Review: Stings of Hymenoptera of the superfamily Vespoidea such as yellow jackets, paper wasps or stinging ants are common triggers for severe and even fatal allergic reactions. Antigen 5 allergens are potent allergens in the majority of these venoms with major importance for diagnosis and therapy. Reviewed here are the characteristics of antigen 5 allergens, their role in component-resolved diagnostics as well as current limitations of the available diagnostics for proper therapeutic decisions. Recent Findings: Antigens 5 are proteins of unknown function in Hymenoptera venoms with high allergenic potency. They represent key elements in component-resolved diagnosis to discriminate between honeybee and vespid venom allergy. However, due to their pronounced cross-reactivity, there are remaining diagnostic and therapeutic challenges that have to be addressed. Summary: Antigens 5 are highly relevant venom allergens of the Vespoidea superfamily. Although their use in component-resolved diagnosis facilitates dissection of cross-reactivity and primary allergy in double sensitization to honeybee and vespid venom, new diagnostic concepts are needed to discriminate between allergies to different vespid species.
KW - Allergen cross-reactivity
KW - Antigen 5
KW - Component-resolved diagnostics
KW - Hymenoptera venom allergy
KW - Polistes dominula venom
KW - Yellow jacket venom
UR - http://www.scopus.com/inward/record.url?scp=85087803949&partnerID=8YFLogxK
U2 - 10.1007/s11882-020-00954-0
DO - 10.1007/s11882-020-00954-0
M3 - Review article
C2 - 32647993
AN - SCOPUS:85087803949
SN - 1529-7322
VL - 20
JO - Current Allergy and Asthma Reports
JF - Current Allergy and Asthma Reports
IS - 10
M1 - 58
ER -