Anticancer and Immunogenic Properties of Cardiac Glycosides

Naira Fernanda Zanchett Schneider; Claudia Cerella; Cláudia Maria Oliveira Simões; Marc Diederich

doi:10.3390/molecules22111932

Anticancer and Immunogenic Properties of Cardiac Glycosides

Naira Fernanda Zanchett Schneider, Claudia Cerella, Cláudia Maria Oliveira Simões, Marc Diederich^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

101 Citations (Scopus)

Abstract

Cardiac glycosides (CGs) are natural compounds widely used in the treatment of several cardiac conditions and more recently have been recognized as potential antitumor compounds. They are known to be ligands for Na/K-ATPase, which is a promising drug target in cancer. More recently, in addition to their antitumor effects, it has been suggested that CGs activate tumor-specific immune responses. This review summarizes the anticancer aspects of CGs as new strategies for immunotherapy and drug repositioning (new horizons for old players), and the possible new targets for CGs in cancer cells.

Original language	English
Article number	1932
Journal	Molecules
Volume	22
Issue number	11
DOIs	https://doi.org/10.3390/molecules22111932
Publication status	Published - Nov 2017
Externally published	Yes

Keywords

Anticancer
Cancer cells
Cardiac glycosides
Cytotoxic effects
Immunogenic cell death
Na/K-ATPase

Access to Document

10.3390/molecules22111932

Cite this

@article{eb785d31b0d14290a531dfea2fc69ef6,

title = "Anticancer and Immunogenic Properties of Cardiac Glycosides",

abstract = "Cardiac glycosides (CGs) are natural compounds widely used in the treatment of several cardiac conditions and more recently have been recognized as potential antitumor compounds. They are known to be ligands for Na/K-ATPase, which is a promising drug target in cancer. More recently, in addition to their antitumor effects, it has been suggested that CGs activate tumor-specific immune responses. This review summarizes the anticancer aspects of CGs as new strategies for immunotherapy and drug repositioning (new horizons for old players), and the possible new targets for CGs in cancer cells.",

keywords = "Anticancer, Cancer cells, Cardiac glycosides, Cytotoxic effects, Immunogenic cell death, Na/K-ATPase",

author = "Schneider, {Naira Fernanda Zanchett} and Claudia Cerella and Sim{\~o}es, {Cl{\'a}udia Maria Oliveira} and Marc Diederich",

year = "2017",

month = nov,

doi = "10.3390/molecules22111932",

language = "English",

volume = "22",

journal = "Molecules",

issn = "1420-3049",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "11",

}

TY - JOUR

T1 - Anticancer and Immunogenic Properties of Cardiac Glycosides

AU - Schneider, Naira Fernanda Zanchett

AU - Cerella, Claudia

AU - Simões, Cláudia Maria Oliveira

AU - Diederich, Marc

PY - 2017/11

Y1 - 2017/11

N2 - Cardiac glycosides (CGs) are natural compounds widely used in the treatment of several cardiac conditions and more recently have been recognized as potential antitumor compounds. They are known to be ligands for Na/K-ATPase, which is a promising drug target in cancer. More recently, in addition to their antitumor effects, it has been suggested that CGs activate tumor-specific immune responses. This review summarizes the anticancer aspects of CGs as new strategies for immunotherapy and drug repositioning (new horizons for old players), and the possible new targets for CGs in cancer cells.

AB - Cardiac glycosides (CGs) are natural compounds widely used in the treatment of several cardiac conditions and more recently have been recognized as potential antitumor compounds. They are known to be ligands for Na/K-ATPase, which is a promising drug target in cancer. More recently, in addition to their antitumor effects, it has been suggested that CGs activate tumor-specific immune responses. This review summarizes the anticancer aspects of CGs as new strategies for immunotherapy and drug repositioning (new horizons for old players), and the possible new targets for CGs in cancer cells.

KW - Anticancer

KW - Cancer cells

KW - Cardiac glycosides

KW - Cytotoxic effects

KW - Immunogenic cell death

KW - Na/K-ATPase

UR - http://www.scopus.com/inward/record.url?scp=85035774535&partnerID=8YFLogxK

U2 - 10.3390/molecules22111932

DO - 10.3390/molecules22111932

M3 - Review article

C2 - 29117117

AN - SCOPUS:85035774535

SN - 1420-3049

VL - 22

JO - Molecules

JF - Molecules

IS - 11

M1 - 1932

ER -

Anticancer and Immunogenic Properties of Cardiac Glycosides

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this