Antibacterial activity of 1-methyl-7-methoxy-beta-carboline and its phenacyl and coumarine analogues.

Z. S. Saify*, Jawaid Farhad, Nousheen Mushtaq, Fozia Noor, Shamim Akhtar, M. Arif, Baqir Shyum Naqvi, Muhammad Harris Shoaib

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Antibacterial activity of 1-methyl-7-methoxy-beta-carboline (harmaline) and its phenacyl and coumarine analogues 1-(3-nitro-phenyl)-(2-(7-methoxy-1-methyl-1,3,4,9-tetrahydro-beta-carbolin-2-yl)-ethanone (II), 1-(3,4-dihydroxy-phenyl)-2-(7-methoxy-1-methyl-1,3,4,9-tetrahydro-beta-carbolin-2-yl)-ethanone (III) 7-(methoxy-beta-carboline),15-24,de-hydro(19,20-dimethoxy)coumarine (IV), 7-(methoxy-beta-carboline)15-24,dehydro(20-methoxy)coumarine (V) were studied by disc diffusion method. All compounds were tested against three gram positive and four gram-negative bacteria. Parent compound showed good activity. All compounds revealed better results against gram positive as compared to gram-negative bacteria. 1-(3,4-Dihydroxy-phenyl)-2-(7-methoxy-1-methyl-1,3,4,9-tetrahydro-beta-carbolin-2-yl)-ethanone (III) was found most potent compound showing broad spectrum activity when compared with all synthesized analogues. Coumarine analogues showed more or less same activity indicating that number and position of methoxy groups are not important regarding antimicrobial activity.

Original languageEnglish
Pages (from-to)39-41
Number of pages3
JournalPakistan Journal of Pharmaceutical Sciences
Volume18
Issue number3
Publication statusPublished - Jul 2005
Externally publishedYes

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