Antiapoptotic effects of budipine

T. Müller*, H. Przuntek, R. Krüger, A. Mackowiak

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review


Apoptosis is one essential step for neuronal death in the nigrostriatal region in patients with Parkinson's disease. Cytotoxic tumor necrosis factor-α (TNF-α) and the proinflammatory cytokine interleukin-6 (Il-6) provide a proapoptotic environment. We investigated the influence of the antiparkinsonian compound budipine on the release of TNF-α and Il-6 in peripheral blood mononuclear cells (PBMC) and on the degree of cisplatin induced apoptotic cell death in SH-SY 5Y human neuroblastoma cells. 10-7, 10-8, 10-9 mol/l of budipine significantly reduced release of TNF-α and Il-6 in PBMC and decreased apoptotic cell death after 50 hours and 74 hours in the SH-SY 5Y cells. Our results suggest, that budipine administration provides an antiapoptotic environment and slows neuronal apoptotic and inflammatory mediated loss of neurons.

Original languageEnglish
Pages (from-to)1365-1373
Number of pages9
JournalJournal of Neural Transmission
Issue number10-11
Publication statusPublished - Oct 2004
Externally publishedYes


  • Alzheimer's disease
  • Apoptosis
  • Budipine
  • Interleukin-6
  • Neurodegeneration
  • Neuroprotection
  • Parkinson's disease
  • Tumor necrosis factor-α


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