Antiapoptotic effects of budipine

T. Müller; H. Przuntek; R. Krüger; A. Mackowiak

doi:10.1007/s00702-004-0157-4

Antiapoptotic effects of budipine

T. Müller^*, H. Przuntek, R. Krüger, A. Mackowiak

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Apoptosis is one essential step for neuronal death in the nigrostriatal region in patients with Parkinson's disease. Cytotoxic tumor necrosis factor-α (TNF-α) and the proinflammatory cytokine interleukin-6 (Il-6) provide a proapoptotic environment. We investigated the influence of the antiparkinsonian compound budipine on the release of TNF-α and Il-6 in peripheral blood mononuclear cells (PBMC) and on the degree of cisplatin induced apoptotic cell death in SH-SY 5Y human neuroblastoma cells. 10^-7, 10^-8, 10^-9 mol/l of budipine significantly reduced release of TNF-α and Il-6 in PBMC and decreased apoptotic cell death after 50 hours and 74 hours in the SH-SY 5Y cells. Our results suggest, that budipine administration provides an antiapoptotic environment and slows neuronal apoptotic and inflammatory mediated loss of neurons.

Original language	English
Pages (from-to)	1365-1373
Number of pages	9
Journal	Journal of Neural Transmission
Volume	111
Issue number	10-11
DOIs	https://doi.org/10.1007/s00702-004-0157-4
Publication status	Published - Oct 2004
Externally published	Yes

Keywords

Alzheimer's disease
Apoptosis
Budipine
Interleukin-6
Neurodegeneration
Neuroprotection
Parkinson's disease
Tumor necrosis factor-α

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title = "Antiapoptotic effects of budipine",

abstract = "Apoptosis is one essential step for neuronal death in the nigrostriatal region in patients with Parkinson's disease. Cytotoxic tumor necrosis factor-α (TNF-α) and the proinflammatory cytokine interleukin-6 (Il-6) provide a proapoptotic environment. We investigated the influence of the antiparkinsonian compound budipine on the release of TNF-α and Il-6 in peripheral blood mononuclear cells (PBMC) and on the degree of cisplatin induced apoptotic cell death in SH-SY 5Y human neuroblastoma cells. 10-7, 10-8, 10-9 mol/l of budipine significantly reduced release of TNF-α and Il-6 in PBMC and decreased apoptotic cell death after 50 hours and 74 hours in the SH-SY 5Y cells. Our results suggest, that budipine administration provides an antiapoptotic environment and slows neuronal apoptotic and inflammatory mediated loss of neurons.",

keywords = "Alzheimer's disease, Apoptosis, Budipine, Interleukin-6, Neurodegeneration, Neuroprotection, Parkinson's disease, Tumor necrosis factor-α",

author = "T. M{\"u}ller and H. Przuntek and R. Kr{\"u}ger and A. Mackowiak",

year = "2004",

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doi = "10.1007/s00702-004-0157-4",

language = "English",

volume = "111",

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journal = "Journal of Neural Transmission",

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TY - JOUR

T1 - Antiapoptotic effects of budipine

AU - Müller, T.

AU - Przuntek, H.

AU - Krüger, R.

AU - Mackowiak, A.

PY - 2004/10

Y1 - 2004/10

N2 - Apoptosis is one essential step for neuronal death in the nigrostriatal region in patients with Parkinson's disease. Cytotoxic tumor necrosis factor-α (TNF-α) and the proinflammatory cytokine interleukin-6 (Il-6) provide a proapoptotic environment. We investigated the influence of the antiparkinsonian compound budipine on the release of TNF-α and Il-6 in peripheral blood mononuclear cells (PBMC) and on the degree of cisplatin induced apoptotic cell death in SH-SY 5Y human neuroblastoma cells. 10-7, 10-8, 10-9 mol/l of budipine significantly reduced release of TNF-α and Il-6 in PBMC and decreased apoptotic cell death after 50 hours and 74 hours in the SH-SY 5Y cells. Our results suggest, that budipine administration provides an antiapoptotic environment and slows neuronal apoptotic and inflammatory mediated loss of neurons.

AB - Apoptosis is one essential step for neuronal death in the nigrostriatal region in patients with Parkinson's disease. Cytotoxic tumor necrosis factor-α (TNF-α) and the proinflammatory cytokine interleukin-6 (Il-6) provide a proapoptotic environment. We investigated the influence of the antiparkinsonian compound budipine on the release of TNF-α and Il-6 in peripheral blood mononuclear cells (PBMC) and on the degree of cisplatin induced apoptotic cell death in SH-SY 5Y human neuroblastoma cells. 10-7, 10-8, 10-9 mol/l of budipine significantly reduced release of TNF-α and Il-6 in PBMC and decreased apoptotic cell death after 50 hours and 74 hours in the SH-SY 5Y cells. Our results suggest, that budipine administration provides an antiapoptotic environment and slows neuronal apoptotic and inflammatory mediated loss of neurons.

KW - Alzheimer's disease

KW - Apoptosis

KW - Budipine

KW - Interleukin-6

KW - Neurodegeneration

KW - Neuroprotection

KW - Parkinson's disease

KW - Tumor necrosis factor-α

UR - http://www.scopus.com/inward/record.url?scp=7944235891&partnerID=8YFLogxK

U2 - 10.1007/s00702-004-0157-4

DO - 10.1007/s00702-004-0157-4

M3 - Article

C2 - 15480843

AN - SCOPUS:7944235891

SN - 0300-9564

VL - 111

SP - 1365

EP - 1373

JO - Journal of Neural Transmission

JF - Journal of Neural Transmission

IS - 10-11

ER -

Antiapoptotic effects of budipine

Abstract

Keywords

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