Anti-cancer effects of naturally derived compounds targeting histone deacetylase 6-related pathways

Manon Lernoux; Michael Schnekenburger; Mario Dicato; Marc Diederich

doi:10.1016/j.phrs.2017.11.004

Anti-cancer effects of naturally derived compounds targeting histone deacetylase 6-related pathways

Manon Lernoux, Michael Schnekenburger, Mario Dicato, Marc Diederich^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

39 Citations (Scopus)

Abstract

Alterations of the epigenetic machinery, affecting multiple biological functions, represent a major hallmark enabling the development of tumors. Among epigenetic regulatory proteins, histone deacetylase (HDAC)6 has emerged as an interesting potential therapeutic target towards a variety of diseases including cancer. Accordingly, this isoenzyme regulates many vital cellular regulatory processes and pathways essential to physiological homeostasis, as well as tumor multistep transformation involving initiation, promotion, progression and metastasis. In this review, we will consequently discuss the critical implications of HDAC6 in distinct mechanisms relevant to physiological and cancerous conditions, as well as the anticancer properties of synthetic, natural and natural-derived compounds through the modulation of HDAC6-related pathways.

Original language	English
Pages (from-to)	337-356
Number of pages	20
Journal	Pharmacological Research
Volume	129
DOIs	https://doi.org/10.1016/j.phrs.2017.11.004
Publication status	Published - Mar 2018
Externally published	Yes

Keywords

Cancer hallmarks
Cancer therapy
HDAC6
HDAC6 inhibitors
Natural compounds

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10.1016/j.phrs.2017.11.004

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title = "Anti-cancer effects of naturally derived compounds targeting histone deacetylase 6-related pathways",

abstract = "Alterations of the epigenetic machinery, affecting multiple biological functions, represent a major hallmark enabling the development of tumors. Among epigenetic regulatory proteins, histone deacetylase (HDAC)6 has emerged as an interesting potential therapeutic target towards a variety of diseases including cancer. Accordingly, this isoenzyme regulates many vital cellular regulatory processes and pathways essential to physiological homeostasis, as well as tumor multistep transformation involving initiation, promotion, progression and metastasis. In this review, we will consequently discuss the critical implications of HDAC6 in distinct mechanisms relevant to physiological and cancerous conditions, as well as the anticancer properties of synthetic, natural and natural-derived compounds through the modulation of HDAC6-related pathways.",

keywords = "Cancer hallmarks, Cancer therapy, HDAC6, HDAC6 inhibitors, Natural compounds",

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AU - Lernoux, Manon

AU - Schnekenburger, Michael

AU - Dicato, Mario

AU - Diederich, Marc

PY - 2018/3

Y1 - 2018/3

N2 - Alterations of the epigenetic machinery, affecting multiple biological functions, represent a major hallmark enabling the development of tumors. Among epigenetic regulatory proteins, histone deacetylase (HDAC)6 has emerged as an interesting potential therapeutic target towards a variety of diseases including cancer. Accordingly, this isoenzyme regulates many vital cellular regulatory processes and pathways essential to physiological homeostasis, as well as tumor multistep transformation involving initiation, promotion, progression and metastasis. In this review, we will consequently discuss the critical implications of HDAC6 in distinct mechanisms relevant to physiological and cancerous conditions, as well as the anticancer properties of synthetic, natural and natural-derived compounds through the modulation of HDAC6-related pathways.

AB - Alterations of the epigenetic machinery, affecting multiple biological functions, represent a major hallmark enabling the development of tumors. Among epigenetic regulatory proteins, histone deacetylase (HDAC)6 has emerged as an interesting potential therapeutic target towards a variety of diseases including cancer. Accordingly, this isoenzyme regulates many vital cellular regulatory processes and pathways essential to physiological homeostasis, as well as tumor multistep transformation involving initiation, promotion, progression and metastasis. In this review, we will consequently discuss the critical implications of HDAC6 in distinct mechanisms relevant to physiological and cancerous conditions, as well as the anticancer properties of synthetic, natural and natural-derived compounds through the modulation of HDAC6-related pathways.

KW - Cancer hallmarks

KW - Cancer therapy

KW - HDAC6

KW - HDAC6 inhibitors

KW - Natural compounds

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DO - 10.1016/j.phrs.2017.11.004

M3 - Review article

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AN - SCOPUS:85033793778

SN - 1043-6618

VL - 129

SP - 337

EP - 356

JO - Pharmacological Research

JF - Pharmacological Research

ER -

Anti-cancer effects of naturally derived compounds targeting histone deacetylase 6-related pathways

Abstract

Keywords

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