Anthropometry and the risk of lung cancer in EPIC

Nikmah Utami Dewi; Hendriek C. Boshuizen; Mattias Johansson; Paolo Vineis; Ellen Kampman; Annika Steffen; Anne Tjønneland; Jytte Halkjær; Kim Overvad; Gianluca Severi; Guy Fagherazzi; Marie Christine Boutron-Ruault; Rudolf Kaaks; Kuanrong Li; Heiner Boeing; Antonia Trichopoulou; Christina Bamia; Eleni Klinaki; Rosario Tumino; Domenico Palli; Amalia Mattiello; Giovanna Tagliabue; Petra H. Peeters; Roel Vermeulen; Elisabete Weiderpass; Inger Torhild Gram; José María Huerta; Antonio Agudo; María José Sánchez; Eva Ardanaz; Miren Dorronsoro; José Ramón Quirós; Emily Sonestedt; Mikael Johansson; Kjell Grankvist; Tim Key; Kay Tee Khaw; Nick Wareham; Amanda J. Cross; Teresa Norat; Elio Riboli; Anouar Fanidi; David Muller; H. Bas Bueno-De-Mesquita

doi:10.1093/aje/kwv298

Anthropometry and the risk of lung cancer in EPIC

Nikmah Utami Dewi, Hendriek C. Boshuizen^*, Mattias Johansson, Paolo Vineis, Ellen Kampman, Annika Steffen, Anne Tjønneland, Jytte Halkjær, Kim Overvad, Gianluca Severi, Guy Fagherazzi, Marie Christine Boutron-Ruault, Rudolf Kaaks, Kuanrong Li, Heiner Boeing, Antonia Trichopoulou, Christina Bamia, Eleni Klinaki, Rosario Tumino, Domenico PalliAmalia Mattiello, Giovanna Tagliabue, Petra H. Peeters, Roel Vermeulen, Elisabete Weiderpass, Inger Torhild Gram, José María Huerta, Antonio Agudo, María José Sánchez, Eva Ardanaz, Miren Dorronsoro, José Ramón Quirós, Emily Sonestedt, Mikael Johansson, Kjell Grankvist, Tim Key, Kay Tee Khaw, Nick Wareham, Amanda J. Cross, Teresa Norat, Elio Riboli, Anouar Fanidi, David Muller, H. Bas Bueno-De-Mesquita

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

23 Citations (Scopus)

Abstract

The associations of body mass index (BMI) and other anthropometric measurements with lung cancer were examined in 348,108 participants in the European Investigation Into Cancer and Nutrition (EPIC) between 1992 and 2010. The study population included 2,400 case patients with incident lung cancer, and the average length of follow-up was 11 years. Hazard ratios were calculated using Cox proportional hazard models in which we modeled smoking variables with cubic splines. Overall, there was a significant inverse association between BMI (weight (kg)/height (m)²) and the risk of lung cancer after adjustment for smoking and other confounders (for BMI of 30.0-34.9 versus 18.5-25.0, hazard ratio = 0.72, 95% confidence interval: 0.62, 0.84). The strength of the association declined with increasing follow-up time. Conversely, after adjustment for BMI, waist circumference and waist-to-height ratio were significantly positively associated with lung cancer risk (for the highest category of waist circumference vs. the lowest, hazard ratio = 1.25, 95% confidence interval: 1.05, 1.50). Given the decline of the inverse association between BMI and lung cancer over time, the association is likely at least partly due to weight loss resulting from preclinical lung cancer that was present at baseline. Residual confounding by smoking could also have influenced our findings.

Original language	English
Pages (from-to)	129-139
Number of pages	11
Journal	American Journal of Epidemiology
Volume	184
Issue number	2
DOIs	https://doi.org/10.1093/aje/kwv298
Publication status	Published - 15 Jul 2016
Externally published	Yes

Keywords

body mass index
lung cancer
obesity
smoking
waist circumference
waist to hip ratio
waist-to-height ratio

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10.1093/aje/kwv298

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Dewi, N. U., Boshuizen, H. C., Johansson, M., Vineis, P., Kampman, E., Steffen, A., Tjønneland, A., Halkjær, J., Overvad, K., Severi, G., Fagherazzi, G., Boutron-Ruault, M. C., Kaaks, R., Li, K., Boeing, H., Trichopoulou, A., Bamia, C., Klinaki, E., Tumino, R., ... Bueno-De-Mesquita, H. B. (2016). Anthropometry and the risk of lung cancer in EPIC. American Journal of Epidemiology, 184(2), 129-139. https://doi.org/10.1093/aje/kwv298

@article{61e677c9f91f44629da199a70fa3903c,

title = "Anthropometry and the risk of lung cancer in EPIC",

abstract = "The associations of body mass index (BMI) and other anthropometric measurements with lung cancer were examined in 348,108 participants in the European Investigation Into Cancer and Nutrition (EPIC) between 1992 and 2010. The study population included 2,400 case patients with incident lung cancer, and the average length of follow-up was 11 years. Hazard ratios were calculated using Cox proportional hazard models in which we modeled smoking variables with cubic splines. Overall, there was a significant inverse association between BMI (weight (kg)/height (m)2) and the risk of lung cancer after adjustment for smoking and other confounders (for BMI of 30.0-34.9 versus 18.5-25.0, hazard ratio = 0.72, 95% confidence interval: 0.62, 0.84). The strength of the association declined with increasing follow-up time. Conversely, after adjustment for BMI, waist circumference and waist-to-height ratio were significantly positively associated with lung cancer risk (for the highest category of waist circumference vs. the lowest, hazard ratio = 1.25, 95% confidence interval: 1.05, 1.50). Given the decline of the inverse association between BMI and lung cancer over time, the association is likely at least partly due to weight loss resulting from preclinical lung cancer that was present at baseline. Residual confounding by smoking could also have influenced our findings.",

keywords = "body mass index, lung cancer, obesity, smoking, waist circumference, waist to hip ratio, waist-to-height ratio",

author = "Dewi, {Nikmah Utami} and Boshuizen, {Hendriek C.} and Mattias Johansson and Paolo Vineis and Ellen Kampman and Annika Steffen and Anne Tj{\o}nneland and Jytte Halkj{\ae}r and Kim Overvad and Gianluca Severi and Guy Fagherazzi and Boutron-Ruault, {Marie Christine} and Rudolf Kaaks and Kuanrong Li and Heiner Boeing and Antonia Trichopoulou and Christina Bamia and Eleni Klinaki and Rosario Tumino and Domenico Palli and Amalia Mattiello and Giovanna Tagliabue and Peeters, {Petra H.} and Roel Vermeulen and Elisabete Weiderpass and Gram, {Inger Torhild} and Huerta, {Jos{\'e} Mar{\'i}a} and Antonio Agudo and S{\'a}nchez, {Mar{\'i}a Jos{\'e}} and Eva Ardanaz and Miren Dorronsoro and Quir{\'o}s, {Jos{\'e} Ram{\'o}n} and Emily Sonestedt and Mikael Johansson and Kjell Grankvist and Tim Key and Khaw, {Kay Tee} and Nick Wareham and Cross, {Amanda J.} and Teresa Norat and Elio Riboli and Anouar Fanidi and David Muller and Bueno-De-Mesquita, {H. Bas}",

note = "Publisher Copyright: {\textcopyright} 2016 The Author 2016. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health.",

year = "2016",

month = jul,

day = "15",

doi = "10.1093/aje/kwv298",

language = "English",

volume = "184",

pages = "129--139",

journal = "American Journal of Epidemiology",

issn = "0002-9262",

publisher = "Oxford University Press",

number = "2",

}

Dewi, NU, Boshuizen, HC, Johansson, M, Vineis, P, Kampman, E, Steffen, A, Tjønneland, A, Halkjær, J, Overvad, K, Severi, G, Fagherazzi, G, Boutron-Ruault, MC, Kaaks, R, Li, K, Boeing, H, Trichopoulou, A, Bamia, C, Klinaki, E, Tumino, R, Palli, D, Mattiello, A, Tagliabue, G, Peeters, PH, Vermeulen, R, Weiderpass, E, Gram, IT, Huerta, JM, Agudo, A, Sánchez, MJ, Ardanaz, E, Dorronsoro, M, Quirós, JR, Sonestedt, E, Johansson, M, Grankvist, K, Key, T, Khaw, KT, Wareham, N, Cross, AJ, Norat, T, Riboli, E, Fanidi, A, Muller, D & Bueno-De-Mesquita, HB 2016, 'Anthropometry and the risk of lung cancer in EPIC', American Journal of Epidemiology, vol. 184, no. 2, pp. 129-139. https://doi.org/10.1093/aje/kwv298

TY - JOUR

T1 - Anthropometry and the risk of lung cancer in EPIC

AU - Dewi, Nikmah Utami

AU - Boshuizen, Hendriek C.

AU - Johansson, Mattias

AU - Vineis, Paolo

AU - Kampman, Ellen

AU - Steffen, Annika

AU - Tjønneland, Anne

AU - Halkjær, Jytte

AU - Overvad, Kim

AU - Severi, Gianluca

AU - Fagherazzi, Guy

AU - Boutron-Ruault, Marie Christine

AU - Kaaks, Rudolf

AU - Li, Kuanrong

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Bamia, Christina

AU - Klinaki, Eleni

AU - Tumino, Rosario

AU - Palli, Domenico

AU - Mattiello, Amalia

AU - Tagliabue, Giovanna

AU - Peeters, Petra H.

AU - Vermeulen, Roel

AU - Weiderpass, Elisabete

AU - Gram, Inger Torhild

AU - Huerta, José María

AU - Agudo, Antonio

AU - Sánchez, María José

AU - Ardanaz, Eva

AU - Dorronsoro, Miren

AU - Quirós, José Ramón

AU - Sonestedt, Emily

AU - Johansson, Mikael

AU - Grankvist, Kjell

AU - Key, Tim

AU - Khaw, Kay Tee

AU - Wareham, Nick

AU - Cross, Amanda J.

AU - Norat, Teresa

AU - Riboli, Elio

AU - Fanidi, Anouar

AU - Muller, David

AU - Bueno-De-Mesquita, H. Bas

PY - 2016/7/15

Y1 - 2016/7/15

N2 - The associations of body mass index (BMI) and other anthropometric measurements with lung cancer were examined in 348,108 participants in the European Investigation Into Cancer and Nutrition (EPIC) between 1992 and 2010. The study population included 2,400 case patients with incident lung cancer, and the average length of follow-up was 11 years. Hazard ratios were calculated using Cox proportional hazard models in which we modeled smoking variables with cubic splines. Overall, there was a significant inverse association between BMI (weight (kg)/height (m)2) and the risk of lung cancer after adjustment for smoking and other confounders (for BMI of 30.0-34.9 versus 18.5-25.0, hazard ratio = 0.72, 95% confidence interval: 0.62, 0.84). The strength of the association declined with increasing follow-up time. Conversely, after adjustment for BMI, waist circumference and waist-to-height ratio were significantly positively associated with lung cancer risk (for the highest category of waist circumference vs. the lowest, hazard ratio = 1.25, 95% confidence interval: 1.05, 1.50). Given the decline of the inverse association between BMI and lung cancer over time, the association is likely at least partly due to weight loss resulting from preclinical lung cancer that was present at baseline. Residual confounding by smoking could also have influenced our findings.

AB - The associations of body mass index (BMI) and other anthropometric measurements with lung cancer were examined in 348,108 participants in the European Investigation Into Cancer and Nutrition (EPIC) between 1992 and 2010. The study population included 2,400 case patients with incident lung cancer, and the average length of follow-up was 11 years. Hazard ratios were calculated using Cox proportional hazard models in which we modeled smoking variables with cubic splines. Overall, there was a significant inverse association between BMI (weight (kg)/height (m)2) and the risk of lung cancer after adjustment for smoking and other confounders (for BMI of 30.0-34.9 versus 18.5-25.0, hazard ratio = 0.72, 95% confidence interval: 0.62, 0.84). The strength of the association declined with increasing follow-up time. Conversely, after adjustment for BMI, waist circumference and waist-to-height ratio were significantly positively associated with lung cancer risk (for the highest category of waist circumference vs. the lowest, hazard ratio = 1.25, 95% confidence interval: 1.05, 1.50). Given the decline of the inverse association between BMI and lung cancer over time, the association is likely at least partly due to weight loss resulting from preclinical lung cancer that was present at baseline. Residual confounding by smoking could also have influenced our findings.

KW - body mass index

KW - lung cancer

KW - obesity

KW - smoking

KW - waist circumference

KW - waist to hip ratio

KW - waist-to-height ratio

UR - http://www.scopus.com/inward/record.url?scp=84980335837&partnerID=8YFLogxK

U2 - 10.1093/aje/kwv298

DO - 10.1093/aje/kwv298

M3 - Article

C2 - 27370791

AN - SCOPUS:84980335837

SN - 0002-9262

VL - 184

SP - 129

EP - 139

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

IS - 2

ER -

Anthropometry and the risk of lung cancer in EPIC

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Keywords

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