Antagonistic role of natural compounds in mTOR-mediated metabolic reprogramming

Claudia Cerella; Anthoula Gaigneaux; Mario Dicato; Marc Diederich

doi:10.1016/j.canlet.2014.02.008

Antagonistic role of natural compounds in mTOR-mediated metabolic reprogramming

Claudia Cerella, Anthoula Gaigneaux, Mario Dicato, Marc Diederich^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

21 Citations (Scopus)

Abstract

Cells reprogram their metabolism very early during carcinogenesis; this event is critical for the establishment of other cancer hallmarks. Many oncogenes and tumor suppressor genes control metabolism by interplaying with the existing nutrient-sensing intracellular pathways. Mammalian target of rapamycin, mTOR, is emerging as a collector and sorter of a metabolic network controlling upstream and downstream modulation of these same genes.Natural compounds represent a source of anti-cancer molecules with chemopreventive and therapeutic properties. This review describes selected pathways and genes orchestrating the metabolic reprogramming and discusses the potential of natural compounds to target oncogenic metabolic aberrations.

Original language	English
Pages (from-to)	251-262
Number of pages	12
Journal	Cancer Letters
Volume	356
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2014.02.008
Publication status	Published - 28 Jan 2015
Externally published	Yes

Keywords

Cancer
Metabolism
MTOR
Natural compounds

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10.1016/j.canlet.2014.02.008

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title = "Antagonistic role of natural compounds in mTOR-mediated metabolic reprogramming",

abstract = "Cells reprogram their metabolism very early during carcinogenesis; this event is critical for the establishment of other cancer hallmarks. Many oncogenes and tumor suppressor genes control metabolism by interplaying with the existing nutrient-sensing intracellular pathways. Mammalian target of rapamycin, mTOR, is emerging as a collector and sorter of a metabolic network controlling upstream and downstream modulation of these same genes.Natural compounds represent a source of anti-cancer molecules with chemopreventive and therapeutic properties. This review describes selected pathways and genes orchestrating the metabolic reprogramming and discusses the potential of natural compounds to target oncogenic metabolic aberrations.",

keywords = "Cancer, Metabolism, MTOR, Natural compounds",

author = "Claudia Cerella and Anthoula Gaigneaux and Mario Dicato and Marc Diederich",

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T1 - Antagonistic role of natural compounds in mTOR-mediated metabolic reprogramming

AU - Cerella, Claudia

AU - Gaigneaux, Anthoula

AU - Dicato, Mario

AU - Diederich, Marc

PY - 2015/1/28

Y1 - 2015/1/28

N2 - Cells reprogram their metabolism very early during carcinogenesis; this event is critical for the establishment of other cancer hallmarks. Many oncogenes and tumor suppressor genes control metabolism by interplaying with the existing nutrient-sensing intracellular pathways. Mammalian target of rapamycin, mTOR, is emerging as a collector and sorter of a metabolic network controlling upstream and downstream modulation of these same genes.Natural compounds represent a source of anti-cancer molecules with chemopreventive and therapeutic properties. This review describes selected pathways and genes orchestrating the metabolic reprogramming and discusses the potential of natural compounds to target oncogenic metabolic aberrations.

AB - Cells reprogram their metabolism very early during carcinogenesis; this event is critical for the establishment of other cancer hallmarks. Many oncogenes and tumor suppressor genes control metabolism by interplaying with the existing nutrient-sensing intracellular pathways. Mammalian target of rapamycin, mTOR, is emerging as a collector and sorter of a metabolic network controlling upstream and downstream modulation of these same genes.Natural compounds represent a source of anti-cancer molecules with chemopreventive and therapeutic properties. This review describes selected pathways and genes orchestrating the metabolic reprogramming and discusses the potential of natural compounds to target oncogenic metabolic aberrations.

KW - Cancer

KW - Metabolism

KW - MTOR

KW - Natural compounds

UR - http://www.scopus.com/inward/record.url?scp=84920148090&partnerID=8YFLogxK

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DO - 10.1016/j.canlet.2014.02.008

M3 - Review article

C2 - 24530513

AN - SCOPUS:84920148090

SN - 0304-3835

VL - 356

SP - 251

EP - 262

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Antagonistic role of natural compounds in mTOR-mediated metabolic reprogramming

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Keywords

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