Ansätze zur Etablierung von Präzisionsmedizin bei der Parkinson-Krankheit mit dem Schwerpunkt Genetik

Translated title of the contribution: Emerging concepts for precision medicine in Parkinson's disease with focus on genetics

Lara Stute, Rejko Krüger*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The diverse and highly individual presentations of Parkinson's disease (PD) as a complex combination of motor and non-motor symptoms are being increasingly well characterised not least through large patient cohorts applying deep phenotyping. However, in terms of treatment of PD, the approach is uniform and purely symptomatic. Better stratification strategies with better precision medicine approaches offer opportunities to improve symptomatic treatment, define first causative therapies and provide more patient-centred care. Insight from targeted therapies for monogenic forms of PD aiming at neuroprotection may pave the way for new mechanism-based interventions also for the more common idiopathic PD. Improved stratification of patients may support symptomatic treatments by predicting treatment efficacy and long-term benefit of current pharmacological or neuromodulatory therapies, e.g. in the context of emerging pharmacogenomic knowledge. Based on asymptomatic carriers with monogenic PD or patients with REM sleep behaviour disorder (RBD), first options for applying preventive treatments emerge. The implications of these treatment strategies in relation to disease progression, and the prospects of their implementation in clinical practice need to be addressed.

Translated title of the contributionEmerging concepts for precision medicine in Parkinson's disease with focus on genetics
Original languageGerman
Pages (from-to)558-566
Number of pages9
JournalFortschritte der Neurologie Psychiatrie
Volume88
Issue number9
DOIs
Publication statusPublished - 1 Sep 2020

Keywords

  • Genetics
  • Parkinson's disease
  • Personalised Medicine
  • Precision Medicine
  • Stratification

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