Animal models for low-grade gliomas

Rolf Bjerkvig, Sébastien Bougnaud, Simone P. Niclou*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Citation (Scopus)


The establishment of animal models for human brain tumors is based on the realization that clear mechanistic information with a functional focus is difficult to obtain in human studies and from the fact that in vitro tumor models do not reflect the physiological complexity of tumors grown in vivo. Animal models for low-grade gliomas have mainly appeared during the last two decades with the development of genetically engineered mice where in particular the platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) systems seem to be important in tumor formation. Also, with the advent of neurosphere culture techniques used to propagate neural stem cells, recent developments indicate that low-grade gliomas can be initiated as xenografts in immunodeficient animals. A major challenge of these models is the time required to tumor development. Nevertheless, it is expected that animal modeling for low-grade gliomas will provide important new insight into the etiology of low-grade tumor development in the years to come.

Original languageEnglish
Title of host publicationDiffuse Low-Grade Gliomas in Adults
Subtitle of host publicationNatural History, Interaction with the Brain, and New Individualized Therapeutic Strategies
PublisherSpringer-Verlag London Ltd
Number of pages11
ISBN (Electronic)9781447122135
ISBN (Print)1447122127, 9781447122128
Publication statusPublished - 1 Jan 2013


  • EGFR
  • Genetically modified mice
  • IDH1
  • IDH2
  • Oligodendroglioma
  • PDGF
  • Xenografts


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