Animal lipocalin allergens

Christiane Hilger*, Annette Kuehn, Francois Hentges

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Abstract

Lipocalins represent the most important group of inhalant animal allergens. For some of them, threedimensional protein structures have been resolved, but their functions are still elusive. Lipocalins generally display a low sequence identity between family members. The characterization of new lipocalin allergens has revealed however that some of them display a high sequence identity to lipocalins from another species. They constitute a new group of potentially cross-reactive molecules which, in addition to serum albumins, may contribute to allergic cross-reactions between animal dander of different species. However, the clinical relevance of cross-reactivity needs to be assessed. Further studies are needed to understand which of these animal lipocalins are the primary allergens and which are cross-reacting molecules. The use of single, well characterized allergens for diagnosis will allow the identification of the sensitizing animal, which is a prerequisite for specific immunotherapy.

Original languageEnglish
Pages (from-to)438-447
Number of pages10
JournalCurrent Allergy and Asthma Reports
Volume12
Issue number5
DOIs
Publication statusPublished - Oct 2012

Keywords

  • Allergen
  • Allergy
  • Arthropod
  • Cat
  • Cattle
  • Cross-reactivity
  • Dog
  • Guinea pig
  • Hamster
  • Horse
  • Lipocalin
  • Mammalian
  • Mouse
  • Rabbit
  • Rat

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