Analysis: Repeated Measures in Clinical Trials: Simple Strategies for Analysis Using Summary Measures

Stephen Senn*, Lynda Stevens, Nish Chaturvedi

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The summary measures approach to analysing repeated measures is described. The circumstances under which it can be advantageous to use such measures are considered. Strategies for baseline adjustment where there are multiple baselines are examined, as is the choice of appropriate summary statistic. A compromise trend/mean measure, regression through the origin, is proposed as being useful under some circumstances An analysis using this measure is illustrated with a suitable example.

Original languageEnglish
Title of host publicationTutorials in Biostatistics, Statistical Methods in Clinical Studies
Publisherwiley
Pages379-395
Number of pages17
Volume1
ISBN (Electronic)9780470023679
ISBN (Print)0470023651, 9780470023655
DOIs
Publication statusPublished - 24 Aug 2005
Externally publishedYes

Keywords

  • Albumin excretion rate (AER)
  • Area under the concentration time curve (AUC)
  • Baseline measurement
  • Independent analysis method
  • Mean of the post-randomization measurements (MEAN)
  • OLS slope estimate
  • Single endpoint
  • Summary measures approach
  • Trend effect

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