Analysis of the snake venom peptidome

Solange M.T. Serrano*, André Zelanis, Eduardo S. Kitano, Alexandre K. Tashima

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

8 Citations (Scopus)

Abstract

Snake venom peptidomes are known to be a large source of molecules with different pharmacological properties. The complexity and variability of snake venoms, the presence of proteinases, and the lack of complete species-specific genome sequences make snake venom peptidome profiling a challenging task that requires especial technical strategies for sample processing and mass spectrometric analysis. Here we describe a method for assessing the content of snake venom peptides and highlight the importance of sampling procedures, as they substantially influence the peptidomic complexity of snake venoms.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages349-358
Number of pages10
DOIs
Publication statusPublished - 2018
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume1719
ISSN (Print)1064-3745

Keywords

  • Mass spectrometry
  • Peptidome
  • Proteinase inhibition
  • Snake venom
  • Solid-phase extraction

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