Analysis of the parkin deletion in sporadic and familial Parkinson's disease

R. Krüger, A. M.M. Vieira-Säcker, W. Kuhn, T. Müller, D. Woitalla, L. Schöls, H. Przuntek, J. T. Epplen, O. Riess*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)


Recently a mutation in the parkin gene has been identified as the cause for an autosomal-recessively inherited form of early onset Parkinson's disease (EOPD). The disease causing minimal deletion has been defined as a homozygous exon 4 loss in the parkin gene among Japanese patients. We investigated 140 sporadic and familial EOPD patients of German ancestry for the exon 4 deletion in the parkin gene. None of our patients exhibited a homozygous deletion of exon 4, suggesting a minor role of this mutation for EOPD in Caucasians. Nevertheless a detailed mutation analysis is warranted to explore the overall significance of mutations in the parkin gene in EOPD.

Original languageEnglish
Pages (from-to)159-163
Number of pages5
JournalJournal of Neural Transmission
Issue number2
Publication statusPublished - 1999
Externally publishedYes


  • Early-onset parkinsonism
  • PARK 2
  • Parkin
  • Parkinson's disease


Dive into the research topics of 'Analysis of the parkin deletion in sporadic and familial Parkinson's disease'. Together they form a unique fingerprint.

Cite this