Analysis of the dynamic co-expression network of heart regeneration in the zebrafish

Sophie Rodius, Ganna Androsova, Lou Götz, Robin Liechti, Isaac Crespo, Susanne Merz, Petr V. Nazarov, Niek De Klein, Céline Jeanty, Juan M. González-Rosa, Arnaud Muller, Francois Bernardin, Simone P. Niclou, Laurent Vallar, Nadia Mercader, Mark Ibberson, Ioannis Xenarios, Francisco Azuaje*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Abstract

The zebrafish has the capacity to regenerate its heart after severe injury. While the function of a few genes during this process has been studied, we are far from fully understanding how genes interact to coordinate heart regeneration. To enable systematic insights into this phenomenon, we generated and integrated a dynamic co-expression network of heart regeneration in the zebrafish and linked systems-level properties to the underlying molecular events. Across multiple post-injury time points, the network displays topological attributes of biological relevance. We show that regeneration steps are mediated by modules of transcriptionally coordinated genes, and by genes acting as network hubs. We also established direct associations between hubs and validated drivers of heart regeneration with murine and human orthologs. The resulting models and interactive analysis tools are available at http://infused.vital-it.ch. Using a worked example, we demonstrate the usefulness of this unique open resource for hypothesis generation and in silico screening for genes involved in heart regeneration.

Original languageEnglish
Article number26822
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - 31 May 2016

Fingerprint

Dive into the research topics of 'Analysis of the dynamic co-expression network of heart regeneration in the zebrafish'. Together they form a unique fingerprint.

Cite this