Alterations of regular and mature monocytes are distinct, and dependent of intensity and duration of exercise

Holger Gabriel*, Axel Urhausen, Lars Brechtel, Hans Josef Müller, Wilfried Kindermann

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Abstract

Circulating monocytes comprise functionally distinct regular (CD14bright+) and mature (CD141low+) cells. Cell surface receptors were determined by three colour flow cytometry in 8 healthy control subjects. Compared to regular monocytes, mature monocytes had lower levels of the high affinity Fcy receptor 1 (CD64), complement receptor 3 (CDllb), CD45RO and higher levels for HLA-DR, LFA-1 (CD11a/CD18), interleukin-2 receptor (CD25), CD45RA and the Fcγ receptor 3 (CD16). Both regular and mature monocytes were measured before and up to three hours after four different types of exercise (Ex) in endurance trained athletes (n=9-16). Immediately after anaerobic exercise of I min with a maximal lactate concentration (lamax) of I2.3 (SD I.4) mmol · l-1 and exhaustive exercise of 24 (SD 8) min with a maximal lactate concentration (lamax) of 7.4 (SD 2.6) mmol· l-1 mature monocytes increased more than regular monocytes. Exhaustive endurance exercise of 87 (SD 21) min [lamax 3.7 (SD I.0)] led to a similar increase of regular and mature monocytes. 15-33 min after a 100km run regular monocytes increased significantly, whereas mature monocytes decreased. Up to three hours after the end of all exercises mature monocytes fell below pre-exercise values. In conclusion, duration and intensity of exercise alter distinct maturation stages of monocytes differently. It is probable that the avidity of adhesion molecules like LFA-1 to their endothelial ligands is increased to enable the firm attachment to the endothelium.

Original languageEnglish
Pages (from-to)179-181
Number of pages3
JournalEuropean Journal of Applied Physiology and Occupational Physiology
Volume69
Issue number2
DOIs
Publication statusPublished - Mar 1994
Externally publishedYes

Keywords

  • Differentiation
  • Exertion
  • LPS receptor
  • Monocytes
  • Phagocytes

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