Alpha-synuclein repeat variants and survival in parkinson's disease

Sun Ju Chung; Joanna M. Biernacka; Sebastian M. Armasu; Kari Anderson; Roberta Frigerio; Jan O. Aasly; Grazia Annesi; Anna Rita Bentivoglio; Laura Brighina; Marie Christine Chartier-Harlin; Stefano Goldwurm; Georgios Hadjigeorgiou; Barbara Jasinska-Myga; Beom Seok Jeon; Yun Joong Kim; Rejko Krüger; Suzanne Lesage; Katerina Markopoulou; George Mellick; Karen E. Morrison; Andreas Puschmann; Eng King Tan; David Crosiers; Jessie Theuns; Christine Van Broeckhoven; Karin Wirdefeldt; Zbigniew K. Wszolek; Alexis Elbaz; Demetrius M. Maraganore; Gilad Yahalom; Yael Orlev; Oren S. Cohen; Evgenia Kozlova; Eitan Friedman; Rivka Inzelberg; Sharon Hassin-Baer

doi:10.1002/mds.25841

Alpha-synuclein repeat variants and survival in parkinson's disease

Sun Ju Chung
, Joanna M. Biernacka
, Sebastian M. Armasu
, Kari Anderson
, Roberta Frigerio
, Jan O. Aasly
, Grazia Annesi
, Anna Rita Bentivoglio
, Laura Brighina
, Marie Christine Chartier-Harlin
, Stefano Goldwurm
, Georgios Hadjigeorgiou
, Barbara Jasinska-Myga
, Beom Seok Jeon
, Yun Joong Kim
, Rejko Krüger
, Suzanne Lesage
, Katerina Markopoulou
, George Mellick
, Karen E. Morrison

Andreas Puschmann, Eng King Tan, David Crosiers, Jessie Theuns, Christine Van Broeckhoven, Karin Wirdefeldt, Zbigniew K. Wszolek, Alexis Elbaz, Demetrius M. Maraganore^*, Gilad Yahalom, Yael Orlev, Oren S. Cohen, Evgenia Kozlova, Eitan Friedman, Rivka Inzelberg, Sharon Hassin-Baer

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

12 Citations (Scopus)

Abstract

Objectives: To determine whether α-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). Methods: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival. Results: Twenty-one sites contributed data for 6,154 cases. There was no significant association between α-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value=0.01). Conclusions: In our large consortium study, α-synuclein REP1 genotypes were not associated with survival in PD. Further studies of α-synuclein's role in disease progression and long-term outcomes are needed.

Original language	English
Pages (from-to)	1053-1057
Number of pages	5
Journal	Movement Disorders
Volume	29
Issue number	8
DOIs	https://doi.org/10.1002/mds.25841
Publication status	Published - Jul 2014
Externally published	Yes

Keywords

Association
Gene
Parkinson's disease
Survival
α-synuclein

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Chung, S. J., Biernacka, J. M., Armasu, S. M., Anderson, K., Frigerio, R., Aasly, J. O., Annesi, G., Bentivoglio, A. R., Brighina, L., Chartier-Harlin, M. C., Goldwurm, S., Hadjigeorgiou, G., Jasinska-Myga, B., Jeon, B. S., Kim, Y. J., Krüger, R., Lesage, S., Markopoulou, K., Mellick, G., ... Hassin-Baer, S. (2014). Alpha-synuclein repeat variants and survival in parkinson's disease. Movement Disorders, 29(8), 1053-1057. https://doi.org/10.1002/mds.25841

@article{0909e09a8eaf454f91219002a8323989,

title = "Alpha-synuclein repeat variants and survival in parkinson's disease",

abstract = "Objectives: To determine whether α-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). Methods: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival. Results: Twenty-one sites contributed data for 6,154 cases. There was no significant association between α-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95\% confidence interval: 1.01-1.10; P value=0.01). Conclusions: In our large consortium study, α-synuclein REP1 genotypes were not associated with survival in PD. Further studies of α-synuclein's role in disease progression and long-term outcomes are needed.",

keywords = "Association, Gene, Parkinson's disease, Survival, α-synuclein",

author = "Chung, \{Sun Ju\} and Biernacka, \{Joanna M.\} and Armasu, \{Sebastian M.\} and Kari Anderson and Roberta Frigerio and Aasly, \{Jan O.\} and Grazia Annesi and Bentivoglio, \{Anna Rita\} and Laura Brighina and Chartier-Harlin, \{Marie Christine\} and Stefano Goldwurm and Georgios Hadjigeorgiou and Barbara Jasinska-Myga and Jeon, \{Beom Seok\} and Kim, \{Yun Joong\} and Rejko Kr{\"u}ger and Suzanne Lesage and Katerina Markopoulou and George Mellick and Morrison, \{Karen E.\} and Andreas Puschmann and Tan, \{Eng King\} and David Crosiers and Jessie Theuns and \{Van Broeckhoven\}, Christine and Karin Wirdefeldt and Wszolek, \{Zbigniew K.\} and Alexis Elbaz and Maraganore, \{Demetrius M.\} and Gilad Yahalom and Yael Orlev and Cohen, \{Oren S.\} and Evgenia Kozlova and Eitan Friedman and Rivka Inzelberg and Sharon Hassin-Baer",

year = "2014",

month = jul,

doi = "10.1002/mds.25841",

language = "English",

volume = "29",

pages = "1053--1057",

journal = "Movement Disorders",

issn = "0885-3185",

publisher = "John Wiley \& Sons Inc.",

number = "8",

}

Chung, SJ, Biernacka, JM, Armasu, SM, Anderson, K, Frigerio, R, Aasly, JO, Annesi, G, Bentivoglio, AR, Brighina, L, Chartier-Harlin, MC, Goldwurm, S, Hadjigeorgiou, G, Jasinska-Myga, B, Jeon, BS, Kim, YJ, Krüger, R, Lesage, S, Markopoulou, K, Mellick, G, Morrison, KE, Puschmann, A, Tan, EK, Crosiers, D, Theuns, J, Van Broeckhoven, C, Wirdefeldt, K, Wszolek, ZK, Elbaz, A, Maraganore, DM, Yahalom, G, Orlev, Y, Cohen, OS, Kozlova, E, Friedman, E, Inzelberg, R & Hassin-Baer, S 2014, 'Alpha-synuclein repeat variants and survival in parkinson's disease', Movement Disorders, vol. 29, no. 8, pp. 1053-1057. https://doi.org/10.1002/mds.25841

TY - JOUR

T1 - Alpha-synuclein repeat variants and survival in parkinson's disease

AU - Chung, Sun Ju

AU - Biernacka, Joanna M.

AU - Armasu, Sebastian M.

AU - Anderson, Kari

AU - Frigerio, Roberta

AU - Aasly, Jan O.

AU - Annesi, Grazia

AU - Bentivoglio, Anna Rita

AU - Brighina, Laura

AU - Chartier-Harlin, Marie Christine

AU - Goldwurm, Stefano

AU - Hadjigeorgiou, Georgios

AU - Jasinska-Myga, Barbara

AU - Jeon, Beom Seok

AU - Kim, Yun Joong

AU - Krüger, Rejko

AU - Lesage, Suzanne

AU - Markopoulou, Katerina

AU - Mellick, George

AU - Morrison, Karen E.

AU - Puschmann, Andreas

AU - Tan, Eng King

AU - Crosiers, David

AU - Theuns, Jessie

AU - Van Broeckhoven, Christine

AU - Wirdefeldt, Karin

AU - Wszolek, Zbigniew K.

AU - Elbaz, Alexis

AU - Maraganore, Demetrius M.

AU - Yahalom, Gilad

AU - Orlev, Yael

AU - Cohen, Oren S.

AU - Kozlova, Evgenia

AU - Friedman, Eitan

AU - Inzelberg, Rivka

AU - Hassin-Baer, Sharon

PY - 2014/7

Y1 - 2014/7

N2 - Objectives: To determine whether α-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). Methods: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival. Results: Twenty-one sites contributed data for 6,154 cases. There was no significant association between α-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value=0.01). Conclusions: In our large consortium study, α-synuclein REP1 genotypes were not associated with survival in PD. Further studies of α-synuclein's role in disease progression and long-term outcomes are needed.

AB - Objectives: To determine whether α-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). Methods: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival. Results: Twenty-one sites contributed data for 6,154 cases. There was no significant association between α-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value=0.01). Conclusions: In our large consortium study, α-synuclein REP1 genotypes were not associated with survival in PD. Further studies of α-synuclein's role in disease progression and long-term outcomes are needed.

KW - Association

KW - Gene

KW - Parkinson's disease

KW - Survival

KW - α-synuclein

UR - https://www.scopus.com/pages/publications/84904431856

U2 - 10.1002/mds.25841

DO - 10.1002/mds.25841

M3 - Article

C2 - 24578302

AN - SCOPUS:84904431856

SN - 0885-3185

VL - 29

SP - 1053

EP - 1057

JO - Movement Disorders

JF - Movement Disorders

IS - 8

ER -

Alpha-synuclein repeat variants and survival in parkinson's disease

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Keywords

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