Rodents and other small domestic and laboratory animals have a high sensitizing potential. For certain rodents, ten or more allergens have been identified. The molecular weight of these allergens ranges from 8. kDa to more than 80. kDa. Lipocalins, weighing about 20. kDa, are major rodent allergens. The proteinic and DNA aspects of four lipocalins (guinea pig Cav p 2 and Cav p3, mouse Mus m1 and rat Rat n 1) have now been characterized. Lipocalins are secreted by the salivary glands and by the ocular Harderian gland; mouse and rat urinary lipocalins, produced in the liver, are secreted in the urine. Serum albumins, characterized by a molecular weight of 67. kDa and a tendency to participate in IgE-mediated cross-reactions, are recognized by the serum of 20 to 30% of patients.
|Translated title of the contribution||Rodent allergy|
|Number of pages||4|
|Journal||Revue Francaise d'Allergologie|
|Publication status||Published - Apr 2012|
- Serum albumin