Adverse life trajectories are a risk factor for sars-cov-2 iga seropositivity

Cyrielle Holuka, Chantal J. Snoeck, Sophie B. Mériaux, Markus Ollert, Rejko Krüger, Jonathan D. Turner*, CON-VINCE Consortium

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review


Asymptomatic individuals, called “silent spreaders” spread SARS-CoV-2 efficiently and have complicated control of the ongoing COVID-19 pandemic. As seen in previous influenza pan-demics, socioeconomic and life-trajectory factors are important in disease progression and outcome. The demographics of the asymptomatic SARS-CoV-2 carriers are unknown. We used the CON-VINCE cohort of healthy, asymptomatic, and oligosymptomatic individuals that is statistically representative of the overall population of Luxembourg for age, gender, and residency to characterise this population. Gender (male), not smoking, and exposure to early-life or adult traumatic experiences increased the risk of IgA seropositivity, and the risk associated with early-life exposure was a dose-dependent metric, while some other known comorbidities of active COVID-19 do not impact it. As prior exposure to adversity is associated with negative psychobiological reactions to external stressors, we recorded psychological wellbeing during the study period. Exposure to traumatic events or concurrent autoimmune or rheumatic disease were associated with a worse evolution of anxiety and depressive symptoms throughout the lockdown period. The unique demographic profile of the “silent spreaders” highlights the role that the early-life period plays in determining our lifelong health trajectory and provides evidence that the developmental origins of health and disease is applicable to infectious diseases.

Original languageEnglish
Article number2159
JournalJournal of Clinical Medicine
Issue number10
Publication statusPublished - 17 May 2021


  • Adult traumatic events
  • COVID-19
  • Early-life adversity
  • Psychosocial adversity
  • Relative risk
  • SARS-CoV-2
  • Serology


Dive into the research topics of 'Adverse life trajectories are a risk factor for sars-cov-2 iga seropositivity'. Together they form a unique fingerprint.

Cite this