Adult-born granule cells mature through two functionally distinct states

János Brunner, Máté Neubrandt, Susan Van-Weert, Tibor Andrási, Felix B. Kleine Borgmann, Sebastian Jessberger, János Szabadics

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Abstract

Adult-born granule cells (ABGCs) are involved in certain forms of hippocampus-dependent learning and memory. It has been proposed that young but functionally integrated ABGCs (4-weeks-old) specifically contribute to pattern separation functions of the dentate gyrus due to their heightened excitability, whereas old ABGCs (>8 weeks old) lose these capabilities. Measuring multiple cellular and integrative characteristics of 3- 10-week-old individual ABGCs, we show that ABGCs consist of two functionally distinguishable populations showing highly distinct input integration properties (one group being highly sensitive to narrow input intensity ranges while the other group linearly reports input strength) that are largely independent of the cellular age and maturation stage, suggesting that 'classmate' cells (born during the same period) can contribute to the network with fundamentally different functions. Thus, ABGCs provide two temporally overlapping but functionally distinct neuronal cell populations, adding a novel level of complexity to our understanding of how life-long neurogenesis contributes to adult brain function.

Original languageEnglish
Article numbere03104
Pages (from-to)e03104
JournaleLife
Volume3
DOIs
Publication statusPublished - 2014
Externally publishedYes
Event29th Annual Scientific Meeting of the European Association for Osseointegration - Geneva, Switzerland
Duration: 29 Sep 20221 Oct 2022
https://eao.org/

Keywords

  • active and passive intrinsic membrane properties
  • adult neurogenesis
  • cellular maturation
  • dentate gyrus
  • input–output function
  • pattern separation

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