Adhesion molecules and cytokine expression in fibromyalgia patients: Increased L-selectin on monocytes and neutrophils

Joana A. Macedo; Judith Hesse; Jonathan D. Turner; Wim Ammerlaan; Andrea Gierens; Dirk H. Hellhammer; Claude P. Muller

doi:10.1016/j.jneuroim.2007.06.002

Adhesion molecules and cytokine expression in fibromyalgia patients: Increased L-selectin on monocytes and neutrophils

Joana A. Macedo, Judith Hesse, Jonathan D. Turner, Wim Ammerlaan, Andrea Gierens, Dirk H. Hellhammer, Claude P. Muller^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

20 Citations (Scopus)

Abstract

Several lines of evidence implicate the immune system in the pathophysiology of fibromyalgia (FM). We investigated the role of cytokines and adhesion molecules involved in immune cell trafficking and the influence of 1.5 mg of dexamethasone (DEX) per os on their expression. L-selectin was elevated on monocytes and neutrophils of FM patients. Differences in group response to DEX were observed for CD11b on NK cells, sICAM-1 and IL-2. This study shows a slight disturbance in the innate immune system of FM patients, and suggests an enhanced adhesion and recruitment of leukocytes to inflammatory sites.

Original language	English
Pages (from-to)	159-166
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	188
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2007.06.002
Publication status	Published - Aug 2007

Keywords

Adhesion molecules
Cytokines
Dexamethasone
Fibromyalgia
Leukocytes

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10.1016/j.jneuroim.2007.06.002

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@article{d8f252450a0343ac9464630e0d75d45f,

title = "Adhesion molecules and cytokine expression in fibromyalgia patients: Increased L-selectin on monocytes and neutrophils",

abstract = "Several lines of evidence implicate the immune system in the pathophysiology of fibromyalgia (FM). We investigated the role of cytokines and adhesion molecules involved in immune cell trafficking and the influence of 1.5 mg of dexamethasone (DEX) per os on their expression. L-selectin was elevated on monocytes and neutrophils of FM patients. Differences in group response to DEX were observed for CD11b on NK cells, sICAM-1 and IL-2. This study shows a slight disturbance in the innate immune system of FM patients, and suggests an enhanced adhesion and recruitment of leukocytes to inflammatory sites.",

keywords = "Adhesion molecules, Cytokines, Dexamethasone, Fibromyalgia, Leukocytes",

author = "Macedo, {Joana A.} and Judith Hesse and Turner, {Jonathan D.} and Wim Ammerlaan and Andrea Gierens and Hellhammer, {Dirk H.} and Muller, {Claude P.}",

note = "Funding Information: This study was supported by the International Research Training Group funded by a DFG Grant GRK 1389/1; the Ministry of Culture, Higher Education and Research, Luxembourg, with a PhD grant to JAM and the Ministry of Health, Luxembourg, with a post-doctoral fellowship to JDT. We also acknowledge the support by the CRP-Sant{\'e}, Luxembourg.",

year = "2007",

month = aug,

doi = "10.1016/j.jneuroim.2007.06.002",

language = "English",

volume = "188",

pages = "159--166",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

number = "1-2",

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TY - JOUR

T1 - Adhesion molecules and cytokine expression in fibromyalgia patients

T2 - Increased L-selectin on monocytes and neutrophils

AU - Macedo, Joana A.

AU - Hesse, Judith

AU - Turner, Jonathan D.

AU - Ammerlaan, Wim

AU - Gierens, Andrea

AU - Hellhammer, Dirk H.

AU - Muller, Claude P.

N1 - Funding Information: This study was supported by the International Research Training Group funded by a DFG Grant GRK 1389/1; the Ministry of Culture, Higher Education and Research, Luxembourg, with a PhD grant to JAM and the Ministry of Health, Luxembourg, with a post-doctoral fellowship to JDT. We also acknowledge the support by the CRP-Santé, Luxembourg.

PY - 2007/8

Y1 - 2007/8

N2 - Several lines of evidence implicate the immune system in the pathophysiology of fibromyalgia (FM). We investigated the role of cytokines and adhesion molecules involved in immune cell trafficking and the influence of 1.5 mg of dexamethasone (DEX) per os on their expression. L-selectin was elevated on monocytes and neutrophils of FM patients. Differences in group response to DEX were observed for CD11b on NK cells, sICAM-1 and IL-2. This study shows a slight disturbance in the innate immune system of FM patients, and suggests an enhanced adhesion and recruitment of leukocytes to inflammatory sites.

AB - Several lines of evidence implicate the immune system in the pathophysiology of fibromyalgia (FM). We investigated the role of cytokines and adhesion molecules involved in immune cell trafficking and the influence of 1.5 mg of dexamethasone (DEX) per os on their expression. L-selectin was elevated on monocytes and neutrophils of FM patients. Differences in group response to DEX were observed for CD11b on NK cells, sICAM-1 and IL-2. This study shows a slight disturbance in the innate immune system of FM patients, and suggests an enhanced adhesion and recruitment of leukocytes to inflammatory sites.

KW - Adhesion molecules

KW - Cytokines

KW - Dexamethasone

KW - Fibromyalgia

KW - Leukocytes

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U2 - 10.1016/j.jneuroim.2007.06.002

DO - 10.1016/j.jneuroim.2007.06.002

M3 - Article

C2 - 17602758

AN - SCOPUS:34447632649

SN - 0165-5728

VL - 188

SP - 159

EP - 166

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Adhesion molecules and cytokine expression in fibromyalgia patients: Increased L-selectin on monocytes and neutrophils

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Keywords

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