@inbook{c93509d64cc24b42899f74bf9ec967a2,
title = "Actin remodeling and vesicular trafficking at the tumor cell side of the immunological synapse direct evasion from cytotoxic lymphocytes",
abstract = "The immune system protects the body against cancer by recognizing and eliminating neoplastic cells. Immune effector cells physically interact with cancer cells through a specialized membrane interface known as the immunological synapse. Such intimate interaction is necessary for immune cell activation and directional killing of target cells. A vast array of studies has established that actin cytoskeleton remodeling and membrane/vesicle trafficking play multiple and critical roles on the immune cell side of the immunological synapse. Increasing evidence supports that dynamic changes in actin cytoskeleton organization and vesicle trafficking also take place on the cancer cell side of the immunological synapse and that such changes are closely intertwined with evasion from immune destruction. In the present article, we review current knowledge of actin and vesicle dynamics in cancer cells during cytotoxic lymphocyte attack and tumor immune evasion.",
keywords = "Actin cytoskeleton, Cancer, Exosomes, Granzymes, Immune evasion, Immunological synapse, Lysosomes, Perforin, Vesicle trafficking",
author = "Biolato, {Andrea Michela} and Liza Filali and Hannah Wurzer and C{\'e}line Hoffmann and Ernesto Gargiulo and Salvatore Valitutti and Cl{\'e}ment Thomas",
note = "Funding Information: Thomas's lab is supported by grants from the National Research Fund (FNR; ACTIVATION C19/BM/13579644), La Fondation Cancer Luxembourg (ACTIMMUNE; FC/2019/02) and Think Pink Lux (Marian Aldred Award). A.M.B. is recipient of a PhD fellowship from Fonds De La Recherche Scientifique (ACTIPHAGY ; FNRS ; T{\'e}l{\'e}vie grant 34979532). H.W. is recipient of a PhD fellowhship from FNR (ACTINK2 ; PRIDE15/10675146/CANBIO). E.G. is recipient of a PhD fellowship grant from FNR (PRIDE15/10675146/CANBIO and INTER/DFG/16/11509946). Valitutti's lab is supported by grants from the Laboratoire d{\textquoteright}Excellence Cancer (TOUCAN) (contract ANR11-LABEX) and from the Ligure Nationale contre le Cancer ({\'e}quipe labelis{\'e}e 2018). Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = jan,
doi = "10.1016/bs.ircmb.2020.07.001",
language = "English",
isbn = "9780128212837",
series = "International Review of Cell and Molecular Biology",
publisher = "Elsevier Inc.",
pages = "99--130",
editor = "Cl{\'e}ment Thomas and Lorenzo Galluzzi",
booktitle = "Actin Cytoskeleton in Cancer Progression and Metastasis - Part B",
address = "United States",
}