Actin cytoskeleton straddling the immunological synapse between cytotoxic lymphocytes and cancer cells

Hannah Wurzer, Céline Hoffmann, Antoun Al Absi, Clément Thomas*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)

Abstract

The immune system is a fundamental part of the tumor microenvironment. In particular, cytotoxic lymphocytes, such as cytolytic T cells and natural killer cells, control tumor growth and disease progression by interacting and eliminating tumor cells. The actin cytoskeleton of cytotoxic lymphocytes engaged in an immunological synapse has received considerable research attention. It has been recognized as a central mediator of the formation and maturation of the immunological synapse, and its signaling and cytolytic activities. In comparison, fewer studies have explored the organization and function of actin filaments on the target cancer cell side of the immunological synapse. However, there is growing evidence that the actin cytoskeleton of cancer cells also undergoes extensive remodeling upon cytotoxic lymphocyte attack, and that such remodeling can alter physical and functional interactions at the immunological synapse. In this article, we review the current knowledge of actin organization and functions at both sides of the immunological synapse between cytotoxic lymphocytes and cancer cells, with particular focus on synapse formation, signaling and cytolytic activity, and immune evasion.

Original languageEnglish
Article number463
JournalCells
Volume8
Issue number5
DOIs
Publication statusPublished - 16 May 2019
Externally publishedYes

Keywords

  • Actin cytoskeleton
  • Cytotoxic T lymphocytes
  • Immune evasion
  • Immune surveillance
  • Immunological synapse
  • Natural killer cells

Fingerprint

Dive into the research topics of 'Actin cytoskeleton straddling the immunological synapse between cytotoxic lymphocytes and cancer cells'. Together they form a unique fingerprint.

Cite this