TY - JOUR
T1 - Acipimox-enhanced 18F-fluorodeoxyglucose positron emission tomography for characterizing and predicting early remodeling in the rat infarct model
AU - Bousquenaud, Mélanie
AU - Maskali, Fatiha
AU - Poussier, Sylvain
AU - Marie, Pierre Yves
AU - Boutley, Henri
AU - Karcher, Gilles
AU - Wagner, Daniel R.
AU - Devaux, Yvan
N1 - Funding Information:
Acknowledgments This study was supported by grants from the National Funds of Research, the Society for Research on Cardiovascular Diseases, the Ministry of Culture, Higher Education and Research of Luxembourg, and the ‘‘Fonda-tion de France’’. M.B. is recipient of a fellowship from the National Funds of Research of Luxembourg (grant # PhD-AFR 08-024).
PY - 2012/8
Y1 - 2012/8
N2 - The ratmyocardial infarction (MI)model is widely used to study left ventricular (LV) remodeling. In this study, acipimox-enhanced 18F-Fluorodeoxyglucose (FDG) gated-positron emission tomography (PET) was assessed for characterizing and predicting early remodeling in the rat infarctmodel.NineteenWistar rats had surgical occlusion of the left anterior descending coronary artery and 7 were sham-operated. PET was scheduled 48 h and 2 weeks later for quantifying MI area and LV function. Segments with<50% of FDG uptake had histological evidence of MI (74 ± 9% decrease in parietal thickness, fibrosis development). At 48 h, MI area was large (>35% of LV) in 6 rats, moderate (15-35% of LV) in 8 rats, limited (<15% of LV) in 5 rats and absent in the 7 sham rats. LV remodeling, assessed through the 2 weeks increase in end-diastolic volume, increased between rats with limited, moderate and large MI (+72 ± 25, +109 ± 56, +190 ± 69 μl, respectively, P = 0.007). This 3-groups classification allowed predicting 44% of the 2weeks increase in end-diastolic volume, and additional 34%were predicted by heart rate at 48 h. The acipimoxenhanced FDG gated-PET technique provides efficient characterization and prediction of early remodeling in the rat infarct model.
AB - The ratmyocardial infarction (MI)model is widely used to study left ventricular (LV) remodeling. In this study, acipimox-enhanced 18F-Fluorodeoxyglucose (FDG) gated-positron emission tomography (PET) was assessed for characterizing and predicting early remodeling in the rat infarctmodel.NineteenWistar rats had surgical occlusion of the left anterior descending coronary artery and 7 were sham-operated. PET was scheduled 48 h and 2 weeks later for quantifying MI area and LV function. Segments with<50% of FDG uptake had histological evidence of MI (74 ± 9% decrease in parietal thickness, fibrosis development). At 48 h, MI area was large (>35% of LV) in 6 rats, moderate (15-35% of LV) in 8 rats, limited (<15% of LV) in 5 rats and absent in the 7 sham rats. LV remodeling, assessed through the 2 weeks increase in end-diastolic volume, increased between rats with limited, moderate and large MI (+72 ± 25, +109 ± 56, +190 ± 69 μl, respectively, P = 0.007). This 3-groups classification allowed predicting 44% of the 2weeks increase in end-diastolic volume, and additional 34%were predicted by heart rate at 48 h. The acipimoxenhanced FDG gated-PET technique provides efficient characterization and prediction of early remodeling in the rat infarct model.
KW - Acipimox
KW - Cardiac remodeling
KW - FDF-PET
KW - Myocardial infarction
KW - Rat
UR - http://www.scopus.com/inward/record.url?scp=84870316792&partnerID=8YFLogxK
U2 - 10.1007/s10554-011-9983-2
DO - 10.1007/s10554-011-9983-2
M3 - Article
C2 - 22116590
AN - SCOPUS:84870316792
SN - 1569-5794
VL - 28
SP - 1407
EP - 1415
JO - International Journal of Cardiovascular Imaging
JF - International Journal of Cardiovascular Imaging
IS - 6
ER -